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EMX2 and TLE2
Number of citations of the paper that reports this interaction (PMID
20211142
)
148
Data Source:
BioGRID
(two hybrid)
EMX2
TLE2
Gene Name
empty spiracles homeobox 2
transducin-like enhancer of split 2
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Extracellular Space
Nucleus
Nucleoplasm
Molecular Function
Protein Binding
Sequence-specific DNA Binding
Transcription Corepressor Activity
Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Anterior/posterior Pattern Specification
Dentate Gyrus Development
Cerebral Cortex Regionalization
Cell Proliferation In Forebrain
Forebrain Cell Migration
Neuron Differentiation
Response To Drug
Renal System Development
Transcription, DNA-templated
Signal Transduction
Notch Signaling Pathway
Organ Morphogenesis
Wnt Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Signaling by NOTCH1 HD Domain Mutants in Cancer
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
APC truncation mutants have impaired AXIN binding
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
TCF7L2 mutants don't bind CTBP
truncated APC mutants destabilize the destruction complex
Signaling by Wnt
deactivation of the beta-catenin transactivating complex
APC truncation mutants are not K63 polyubiquitinated
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
S37 mutants of beta-catenin aren't phosphorylated
Degradation of beta-catenin by the destruction complex
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
RNF mutants show enhanced WNT signaling and proliferation
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Signaling by NOTCH1 in Cancer
truncations of AMER1 destabilize the destruction complex
FBXW7 Mutants and NOTCH1 in Cancer
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
formation of the beta-catenin:TCF transactivating complex
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
repression of WNT target genes
NOTCH1 Intracellular Domain Regulates Transcription
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
TCF dependent signaling in response to WNT
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Signaling by WNT in cancer
Drugs
Diseases
GWAS
Airflow obstruction (
22837378
)
Cardiac repolarization (
22683750
)
Obesity-related traits (
23251661
)
Pulmonary function in asthmatics (
23541324
)
Protein-Protein Interactions
4 interactors:
EIF4E
GTF2A1L
MEIS1
TLE2
16 interactors:
BARHL1
EMX2
FOXA3
H3F3A
HES1
HMGB1
LEF1
MSX1
MSX2
PAX9
PRDM1
RUNX1
TLE1
TLX3
UTY
VENTX
Entrez ID
2018
7089
HPRD ID
02495
03025
Ensembl ID
ENSG00000170370
ENSG00000065717
Uniprot IDs
Q04743
B4DE62
K7EMK7
Q04725
PDB IDs
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Regulation Of Gene Expression
Cellular Nitrogen Compound Metabolic Process
Megakaryocyte Development
Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Megakaryocyte Differentiation
Definitive Hemopoiesis
Nuclear-transcribed MRNA Poly(A) Tail Shortening
Lens Morphogenesis In Camera-type Eye
Organ Development
Transcription From RNA Polymerase II Promoter
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Regulation Of Metabolic Process
Organ Morphogenesis
Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of DNA Binding
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Multicellular Organismal Development
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
System Development
Organ Morphogenesis
Developmental Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Anatomical Structure Development
RNA Biosynthetic Process
Anterior/posterior Pattern Specification
Cell Migration
Regulation Of Binding
Positive Regulation Of Transcription, DNA-templated
Cell Motility
Mesenchymal Cell Development
Cell Differentiation
Positive Regulation Of Mesenchymal Cell Apoptotic Process
Embryonic Nail Plate Morphogenesis
Gene Expression
Central Nervous System Development
Odontogenesis
Mesenchymal Cell Differentiation
Face Morphogenesis
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of BMP Signaling Pathway
Nucleobase-containing Compound Metabolic Process
Activation Of Meiosis
Generation Of Neurons
Head Morphogenesis
Positive Regulation Of Cellular Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Tagcloud
?
bmp
cortico
demethylase
depolarizing
differentiative
doubled
egfp
foxg1
h3k27
h3k4m2
hdacs
hmtase
identities
lentivirus
lhx2
mix
neuron
nsc
pax6
pulses
reprogramme
reprogrammed
reprogramming
sox1
specification
teton
tgfbeta
transgenes
trp53
Tagcloud (Difference)
?
bmp
cortico
demethylase
depolarizing
differentiative
doubled
egfp
foxg1
h3k27
h3k4m2
hdacs
hmtase
identities
lentivirus
lhx2
mix
neuron
nsc
pax6
pulses
reprogramme
reprogrammed
reprogramming
sox1
specification
teton
tgfbeta
transgenes
trp53
Tagcloud (Intersection)
?