MMP13 and BCAN

Number of citations of the paper that reports this interaction (PMID 10986281)
28

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MMP13	BCAN
Gene Name		matrix metallopeptidase 13 (collagenase 3)	brevican
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Anchored Component Of Membrane Lysosomal Lumen
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding	Extracellular Matrix Structural Constituent Hyaluronic Acid Binding Carbohydrate Binding
	Biological Process	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Cellular Protein Metabolic Process Bone Morphogenesis	Skeletal System Development Carbohydrate Metabolic Process Cell Adhesion Central Nervous System Development Pathogenesis Hippocampus Development Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Small Molecule Metabolic Process
Pathways		Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ADAMTS5 BCAN CCL7 COL2A1 F12 LRP1 MMP14 TIMP3	10 interactors: ADAMTS4 FBLN2 MMP1 MMP10 MMP13 MMP2 MMP3 MMP7 MMP8 TNR
Entrez ID		4322	63827
HPRD ID		02522	02644
Ensembl ID		ENSG00000137745	ENSG00000132692
Uniprot IDs		A8K846 G5E971 P45452 Q53H33	Q96GW7
PDB IDs		1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 830C
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endochondral Ossification Response To External Stimulus Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Glycoprotein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Beta-amyloid Clearance Multicellular Organismal Metabolic Process Proteoglycan Metabolic Process Zymogen Activation Response To Organic Substance Factor XII Activation Skeletal System Development Bone Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Fibrinolysis Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Plasminogen Activation Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Cardiovascular System Development Astrocyte Cell Migration Bone Development Protein Processing Eosinophil Chemotaxis Protein Metabolic Process Eosinophil Migration Chondrocyte Proliferation Cellular Response To Ethanol Response To Stimulus Protein Autoprocessing Limb Bud Formation Plasma Kallikrein-kinin Cascade Skeletal System Morphogenesis Protein O-linked Fucosylation Dermatan Sulfate Biosynthetic Process Ossification Regulation Of Phospholipase A2 Activity	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Endodermal Cell Differentiation Endoderm Formation Protein Metabolic Process Cellular Response To Amino Acid Stimulus Antibacterial Peptide Secretion Antibacterial Peptide Biosynthetic Process Negative Regulation Of Axon Extension Involved In Regeneration Endoderm Development Response To Amino Acid Formation Of Primary Germ Layer Skeletal System Development Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Gastrulation Defense Response To Bacterium Positive Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Axon Regeneration Positive Regulation Of Oxidative Stress-induced Cell Death Intramembranous Ossification Regulation Of Hydrogen Peroxide Metabolic Process Bone Trabecula Formation Response To External Stimulus Regulation Of Transmission Of Nerve Impulse Locomotory Exploration Behavior Blood Vessel Maturation Skeletal System Morphogenesis Cellular Response To Nitric Oxide Ossification Neuron Cell-cell Adhesion Response To Nitric Oxide Positive Regulation Of Cellular Component Biogenesis Bone Trabecula Morphogenesis Regulation Of Axon Regeneration Regulation Of Protein Complex Assembly Growth Plate Cartilage Development Response To Stress Positive Regulation Of Synaptic Transmission, Glutamatergic Cellular Response To Reactive Nitrogen Species
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized	abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized	abundant astrocytes basic cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal ncam1 nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Intersection) ?