MMP13 and CCL7

Number of citations of the paper that reports this interaction (PubMedID 10947989)
0

Data Source:
HPRD (in vitro, in vivo)

		MMP13	CCL7
Description		matrix metallopeptidase 13	C-C motif chemokine ligand 7
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Collagen Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Cytokine Activity Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Bone Morphogenesis Response To Amyloid-beta	Monocyte Chemotaxis Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cytoskeleton Organization Signal Transduction Canonical NF-kappaB Signal Transduction Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Cell Migration Eosinophil Chemotaxis Positive Regulation Of Inflammatory Response Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures RUNX2 regulates genes involved in cell migration	Chemokine receptors bind chemokines
Drugs		Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 4-methoxybenzenesulfinate PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] Endostatin TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE CTS-1027 BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases		Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Diisocyanate-induced asthma ( 25918132) Peanut allergy ( 29030101)	Blood protein levels ( 30072576) Crohn's disease ( 21102463 22412388 28067908) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)
Interacting Genes		9 interacting genes: ADAMTS5 BCAN CCL7 COL2A1 F12 FBXO7 LRP1 MMP14 TIMP3	18 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 CXCL6 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1 UBQLN2 XCL2
Entrez ID		4322	6354
HPRD ID		02522	01150
Ensembl ID		ENSG00000137745	ENSG00000108688
Uniprot IDs		P45452 Q53H33	P80098
PDB IDs		1EUB 1FLS 1FM1 1PEX 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3WV1 3WV2 3WV3 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 4JP4 4JPA 4L19 5B5O 5B5P 5BOT 5BOY 5BPA 5UWK 5UWL 5UWM 5UWN 7JU8 830C	1BO0 1NCV 4ZKC 7S58 7S59 7SCU 8FJ3 8FK6 8FK8 8JPS
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Extracellular Space Head Development Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Localization To Plasma Membrane Regulation Of Extracellular Matrix Disassembly Endochondral Ossification Regulation Of Protein Localization To Membrane Skeletal System Development Zymogen Activation Extracellular Matrix Organization Extracellular Structure Organization Extracellular Region Regulation Of Metabolic Process Regulation Of Protein Processing Regulation Of Protein Maturation Fatty Acid-CoA Ligase Activity Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Cellular Response To Genistein Extracellular Matrix Disassembly Negative Regulation Of GDF15-GFRAL Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Extracellular Matrix Organization Bone Development Positive Regulation Of Protein Localization To Cell Periphery Embryonic Skeletal System Morphogenesis Plasma Kallikrein-kinin Cascade Regulation Of Proteolysis Factor XII Activation Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Endopeptidase Activity Metalloendopeptidase Activity Basement Membrane Positive Regulation Of Mononuclear Cell Migration Collagen Type II Trimer Positive Regulation Of Phosphatidylcholine Biosynthetic Process Lipoprotein Particle Receptor Binding Golgi Lumen Response To Odorant Lewy Body Core	Chemokine-mediated Signaling Pathway C-C Chemokine Binding Chemokine Receptor Activity C-C Chemokine Receptor Activity Cell Chemotaxis Chemotaxis Locomotion Cytokine-mediated Signaling Pathway Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Cell Migration Cell Surface Receptor Signaling Pathway Calcium-mediated Signaling Endopeptidase Activity Metalloendopeptidase Activity Cell Motility G Protein-coupled Receptor Signaling Pathway Cellular Response To UV-A G Protein-coupled Receptor Activity Metallopeptidase Activity Response To UV-A Serine-type Endopeptidase Activity Chemokine (C-C Motif) Ligand 5 Binding Inflammatory Response Immune System Process External Side Of Plasma Membrane Immune Response Response To Stress Extracellular Structure Organization Extracellular Matrix Organization Leukocyte Chemotaxis Chemokine Binding Intracellular Signaling Cassette Response To Amyloid-beta Defense Response Extracellular Matrix Leukocyte Migration Peptidase Activity Cellular Response To UV Signal Transduction Dendritic Cell Chemotaxis Positive Regulation Of ERAD Pathway Mononuclear Cell Migration Proteolysis Cellular Response To Light Stimulus Plasma Membrane Response To Cytokine Dendritic Cell Migration
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