MMP13 and F12

Number of citations of the paper that reports this interaction (PMID 10930399)
18

Data Source:
HPRD (in vivo)

		MMP13	F12
Gene Name		matrix metallopeptidase 13 (collagenase 3)	coagulation factor XII (Hageman factor)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Calcium Ion Binding Collagen Binding Zinc Ion Binding	Serine-type Endopeptidase Activity Protein Binding Misfolded Protein Binding Serine-type Aminopeptidase Activity
	Biological Process	Endochondral Ossification Growth Plate Cartilage Development Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Bone Mineralization Collagen Catabolic Process Cellular Protein Metabolic Process Bone Morphogenesis	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis
Pathways		Collagen formation Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures	Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs		Marimastat 3-Methylpyridine 2-{4-[4-(4-Chloro-Phenoxy)-Benzenesulfonyl]-Tetrahydro-Pyran-4-Yl}-N-Hydroxy-Acetamide WAY-151693 Hydroxyaminovaline 1-Methyloxy-4-Sulfone-Benzene PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-(4-FLUORO-3-METHYL-BENZYLAMIDE) PYRIMIDINE-4,6-DICARBOXYLIC ACID BIS-[(PYRIDIN-3-YLMETHYL)-AMIDE] TERT-BUTYL 4-({[4-(BUT-2-YN-1-YLAMINO)PHENYL]SULFONYL}METHYL)-4-[(HYDROXYAMINO)CARBONYL]PIPERIDINE-1-CARBOXYLATE 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID 5-(2-ETHOXYETHYL)-5-[4-(4-FLUOROPHENOXY)PHENOXY]PYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE BENZYL 6-BENZYL-5,7-DIOXO-6,7-DIHYDRO-5H-[1,3]THIAZOLO[3,2-C]PYRIMIDINE-2-CARBOXYLATE
Diseases
GWAS			Activated partial thromboplastin time ( 22703881 20303064) Chronic kidney disease ( 20383146) Circulating vasoactive peptide levels ( 23381795) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496)
Protein-Protein Interactions		8 interactors: ADAMTS5 BCAN CCL7 COL2A1 F12 LRP1 MMP14 TIMP3	15 interactors: APOH APP CD93 EPAS1 GP1BA KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N
Entrez ID		4322	2161
HPRD ID		02522	01992
Ensembl ID		ENSG00000137745	ENSG00000131187
Uniprot IDs		A8K846 G5E971 P45452 Q53H33	P00748 Q8IZZ5
PDB IDs		1EUB 1FLS 1FM1 1PEX 1UC1 1XUC 1XUD 1XUR 1YOU 1ZTQ 2D1N 2E2D 2OW9 2OZR 2PJT 2YIG 3ELM 3I7G 3I7I 3KEC 3KEJ 3KEK 3KRY 3LJZ 3O2X 3TVC 3ZXH 456C 4A7B 4FU4 4FVL 4G0D 830C	4BDW 4BDX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Endochondral Ossification Response To External Stimulus Collagen Catabolic Process Collagen Metabolic Process Endochondral Bone Morphogenesis Glycoprotein Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Beta-amyloid Clearance Multicellular Organismal Metabolic Process Proteoglycan Metabolic Process Zymogen Activation Response To Organic Substance Factor XII Activation Skeletal System Development Bone Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Cell Migration Regulation Of Cell Motility Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Fibrinolysis Embryonic Skeletal System Development Visual Perception Sensory Perception Of Light Stimulus Positive Regulation Of Plasminogen Activation Positive Regulation Of Natural Killer Cell Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Cardiovascular System Development Astrocyte Cell Migration Bone Development Protein Processing Eosinophil Chemotaxis Protein Metabolic Process Eosinophil Migration Chondrocyte Proliferation Cellular Response To Ethanol Response To Stimulus Protein Autoprocessing Limb Bud Formation Plasma Kallikrein-kinin Cascade Skeletal System Morphogenesis Protein O-linked Fucosylation Dermatan Sulfate Biosynthetic Process Ossification Regulation Of Phospholipase A2 Activity	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Polyubiquitination Proteolysis Negative Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Toll-like Receptor 4 Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Hypoxia Fibrinolysis Regulation Of Wound Healing Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Protein Activation Cascade Catabolic Process Positive Regulation Of Innate Immune Response Innate Immune Response Defense Response Collagen Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Plasminogen Activation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Collagen Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Multicellular Organismal Macromolecule Metabolic Process Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Protein Ubiquitination Multicellular Organismal Metabolic Process
Tagcloud ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized	amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved
Tagcloud (Difference) ?		advantages akt array chaperone clinicopathological clu clusterin complexing confers correlations ectopic eif3i eukaryotic facilitates forced hcc hepatocellular inhibiting metalloproteinase metastasis ogx option proliferative promoted shorter silencing suppressing turn utilized	amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved
Tagcloud (Intersection) ?