PIGC and DPM2

Number of citations of the paper that reports this interaction (PMID 10944123)
28

Data Source:
HPRD (in vitro)

		PIGC	DPM2
Gene Name		phosphatidylinositol glycan anchor biosynthesis, class C	dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Dolichol-phosphate-mannose Synthase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Catalytic Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Enzyme Regulator Activity
	Biological Process	C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Post-translational Protein Modification Cellular Protein Metabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein N-linked Glycosylation Via Asparagine Dolichol Metabolic Process Regulation Of Protein Stability Protein O-linked Mannosylation Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Catalytic Activity
Pathways		Synthesis of glycosylphosphatidylinositol (GPI) Post-translational protein modification Post-translational modification: synthesis of GPI-anchored proteins	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective MOGS causes MOGS-CDG (CDG-2b) Synthesis of glycosylphosphatidylinositol (GPI) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Synthesis of dolichyl-phosphate mannose Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Post-translational modification: synthesis of GPI-anchored proteins Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Synthesis of dolichyl-phosphate mannose Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-Protein Interactions		4 interactors: DPM2 KLF10 PIGQ ZHX1	6 interactors: DPM1 DPM3 HLA-DMB PIGA PIGC VKORC1
Entrez ID		5279	8818
HPRD ID		03433	16028
Ensembl ID		ENSG00000135845	ENSG00000136908
Uniprot IDs		Q92535	O94777
PDB IDs
Enriched GO Terms of Interacting Partners?		Preassembly Of GPI Anchor In ER Membrane C-terminal Protein Lipidation GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Cellular Macromolecule Biosynthetic Process Phospholipid Biosynthetic Process Macromolecule Biosynthetic Process Dolichol Metabolic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Biosynthetic Process Protein O-linked Mannosylation Protein Mannosylation Lipid Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Mannosylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Bone Mineralization Positive Regulation Of Myeloid Leukocyte Differentiation Dolichol-linked Oligosaccharide Biosynthetic Process Cellular Lipid Metabolic Process Organophosphate Metabolic Process Carbohydrate Metabolic Process Regulation Of Osteoclast Differentiation Somatic Stem Cell Maintenance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Biomineral Tissue Development Protein O-linked Glycosylation Lipid Metabolic Process Regulation Of Circadian Rhythm Protein N-linked Glycosylation Via Asparagine Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	C-terminal Protein Lipidation Post-translational Protein Modification GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Protein O-linked Mannosylation Lipid Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Protein Mannosylation Mannosylation Cellular Lipid Metabolic Process Organophosphate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Lipid Metabolic Process Protein O-linked Glycosylation Cellular Protein Modification Process Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein N-linked Glycosylation Via Asparagine Protein N-linked Glycosylation Dolichol Metabolic Process Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Protein C-linked Glycosylation Via 2'-alpha-mannosyl-L-tryptophan Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Assembly Vitamin K Metabolic Process Phosphate-containing Compound Metabolic Process Macromolecule Glycosylation Protein Glycosylation Glycosylation Protein Metabolic Process Peptidyl-glutamic Acid Carboxylation Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process GDP-mannose Metabolic Process Quinone Metabolic Process
Tagcloud ?		1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants dnm3 enlargement expansive forward iccad illumina intima metabochip pooling proxy q remodelling rs3768445 rs4916251 snp
Tagcloud (Difference) ?		1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants dnm3 enlargement expansive forward iccad illumina intima metabochip pooling proxy q remodelling rs3768445 rs4916251 snp
Tagcloud (Intersection) ?