PIGC and KLF10

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PIGC	KLF10
Gene Name		phosphatidylinositol glycan anchor biosynthesis, class C	Kruppel-like factor 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus
	Molecular Function	Catalytic Activity Phosphatidylinositol N-acetylglucosaminyltransferase Activity	Core Promoter Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	C-terminal Protein Lipidation GPI Anchor Biosynthetic Process Preassembly Of GPI Anchor In ER Membrane Post-translational Protein Modification Cellular Protein Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Development Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Circadian Rhythm Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Cellular Response To Peptide
Pathways		Synthesis of glycosylphosphatidylinositol (GPI) Post-translational protein modification Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Waist-hip ratio ( 20935629)
Protein-Protein Interactions		4 interactors: DPM2 KLF10 PIGQ ZHX1	13 interactors: BOP1 CDK6 CRIP2 KAT2B LENG1 LRRC75A-AS1 PIGC RPL14 SF3B3 SIN3A SP1 TNS1 ZNF512B
Entrez ID		5279	7071
HPRD ID		03433	03527
Ensembl ID		ENSG00000135845	ENSG00000155090
Uniprot IDs		Q92535	Q13118
PDB IDs			2EPA
Enriched GO Terms of Interacting Partners?		Preassembly Of GPI Anchor In ER Membrane C-terminal Protein Lipidation GPI Anchor Biosynthetic Process GPI Anchor Metabolic Process Glycolipid Biosynthetic Process Protein Lipidation Lipoprotein Biosynthetic Process Phosphatidylinositol Biosynthetic Process Glycolipid Metabolic Process Lipoprotein Metabolic Process Glycerophospholipid Biosynthetic Process Post-translational Protein Modification Phosphatidylinositol Metabolic Process Membrane Lipid Metabolic Process Cellular Macromolecule Biosynthetic Process Phospholipid Biosynthetic Process Macromolecule Biosynthetic Process Dolichol Metabolic Process Glycerophospholipid Metabolic Process Glycerolipid Metabolic Process Phospholipid Metabolic Process Biosynthetic Process Protein O-linked Mannosylation Protein Mannosylation Lipid Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Mannosylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Bone Mineralization Positive Regulation Of Myeloid Leukocyte Differentiation Dolichol-linked Oligosaccharide Biosynthetic Process Cellular Lipid Metabolic Process Organophosphate Metabolic Process Carbohydrate Metabolic Process Regulation Of Osteoclast Differentiation Somatic Stem Cell Maintenance Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Myeloid Cell Differentiation Biomineral Tissue Development Protein O-linked Glycosylation Lipid Metabolic Process Regulation Of Circadian Rhythm Protein N-linked Glycosylation Via Asparagine Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process	Hematopoietic Progenitor Cell Differentiation Ribosomal Large Subunit Biogenesis Hemopoiesis Immune System Development RNA Metabolic Process Rhythmic Process Response To Methylglyoxal Sequestering Of Nodal From Receptor Via Nodal Binding Cell Dedifferentiation Negative Regulation Of Histone H3-K27 Acetylation Regulation Of Cell Cycle Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Negative Regulation Of Nodal Signaling Pathway Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Chromatin Silencing RRNA Processing RRNA Metabolic Process Notch Signaling Pathway Viral Process Cell Cycle Arrest Determination Of Left/right Asymmetry In Lateral Mesoderm Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Nodal Signaling Pathway Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Maturation Of LSU-rRNA Gene Expression Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Sequestering Of Extracellular Ligand From Receptor Ribosome Biogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Cellular Senescence Cellular Nitrogen Compound Metabolic Process Positive Regulation By Host Of Viral Transcription Fibroblast Migration Regulation Of Protein Glycosylation Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Embryonic Process Involved In Female Pregnancy DNA-templated Transcription, Initiation N-terminal Protein Amino Acid Acetylation Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Tagcloud ?		1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants dnm3 enlargement expansive forward iccad illumina intima metabochip pooling proxy q remodelling rs3768445 rs4916251 snp	acetyltransferase advance antagonistic associate characterize epigenetically foxp3 indeed inducibility inherited integrate integrated interacting kruppel modifying nh2 pcaf physically recapitulated reciprocal renders reporter repressor sin3 studying toggle underlie underlies works
Tagcloud (Difference) ?		1q24 200k aaa adventitial aneurysm aortic atherosclerosis atherosclerotic c1orf105 carotid cimt cohorts compensatory determinants dnm3 enlargement expansive forward iccad illumina intima metabochip pooling proxy q remodelling rs3768445 rs4916251 snp	acetyltransferase advance antagonistic associate characterize epigenetically foxp3 indeed inducibility inherited integrate integrated interacting kruppel modifying nh2 pcaf physically recapitulated reciprocal renders reporter repressor sin3 studying toggle underlie underlies works
Tagcloud (Intersection) ?