THOP1 and PALS2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		THOP1	PALS2
Description		thimet oligopeptidase 1	protein associated with LIN7 2, MAGUK p55 family member
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Intermembrane Space Cytosol	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Protein Polyubiquitination Proteolysis Peptide Metabolic Process	Protein-containing Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		10 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2 TTC3	31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1
Entrez ID		7064	51678
HPRD ID		03072	09509
Ensembl ID		ENSG00000172009	ENSG00000105926
Uniprot IDs		P52888	B8ZZG1 Q9NZW5
PDB IDs		1S4B 2O36
Enriched GO Terms of Interacting Partners?		Calcium-mediated Signaling Positive Regulation Of Cholesterol Metabolic Process Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Blood Circulation Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Sperm Midpiece Angiotensin Type I Receptor Activity Regulation Of Interleukin-2 Production TORC1 Signaling TORC2 Complex Disassembly Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Bradykinin Receptor Binding Positive Regulation Of Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Negative Regulation Of TOR Signaling TOR Signaling TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Calcium-mediated Signaling Angiotensin Type II Receptor Activity Intracellular Signal Transduction Phospholipase C-activating Angiotensin-activated Signaling Pathway Renal System Process Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Steroid Metabolic Process Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Heart Rate Regulation Of Striated Muscle Contraction Regulation Of TORC1 Signaling Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Metabolic Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
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