THOP1 and AGTR1

Number of citations of the paper that reports this interaction (PMID 15376229)
3

Data Source:
HPRD (in vitro, two hybrid)

		THOP1	AGTR1
Gene Name		thimet oligopeptidase 1	angiotensin II receptor, type 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding	Angiotensin Type I Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Peptide Metabolic Process Intracellular Signal Transduction	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Vasodilation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Valsartan Olmesartan Losartan Candesartan Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan Azilsartan medoxomil
Diseases
GWAS
Protein-Protein Interactions		6 interactors: AGTR1 CALM1 MPHOSPH6 MPP6 PRKACA TRAF2	20 interactors: ADRBK1 ADRBK2 AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 RAB5A RAF1 THOP1 ZBTB16
Entrez ID		7064	185
HPRD ID		03072	00107
Ensembl ID		ENSG00000172009	ENSG00000144891
Uniprot IDs		P52888	D3DNG8 P30556 Q53YY0 Q6NUP5 Q8TBK4
PDB IDs		1S4B 2O36	1ZV0
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Lipase Activity Calcium-mediated Signaling Second-messenger-mediated Signaling Regulation Of Ion Homeostasis Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Maturation Of 5.8S RRNA Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of Lyase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cyclase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Protein Kinase Activity Regulation Of Oxidoreductase Activity Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Phototransduction, Visible Light Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Kinase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Positive Regulation Of Catalytic Activity Positive Regulation Of Inflammatory Response Positive Regulation Of Transferase Activity Renal System Process Positive Regulation Of Dense Core Granule Biogenesis Phospholipase C-activating Angiotensin-activated Signaling Pathway	Regulation Of Signaling Positive Regulation Of MAPK Cascade Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Receptor Internalization Negative Regulation Of Signaling Regulation Of MAPK Cascade Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Blood Coagulation Hemostasis Activation Of Protein Kinase Activity Negative Regulation Of Cell Death Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Cell Surface Receptor Signaling Pathway Regulation Of Body Fluid Levels Positive Regulation Of Phosphorylation Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Peptidyl-serine Phosphorylation Regulation Of Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transport Activation Of Phospholipase C Activity Response To Abiotic Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Phospholipase C Activity Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration
Tagcloud ?		adjacent array arrays assessing biomarker cirrhosis cn considering correlations gapdh hcc hepatitis hepatocellular insufficient intrahepatic liver matching multicentric nonneoplastic oligopeptidase prediction profiling recurs resected sn supernormal termed thimet transcriptase	125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Difference) ?		adjacent array arrays assessing biomarker cirrhosis cn considering correlations gapdh hcc hepatitis hepatocellular insufficient intrahepatic liver matching multicentric nonneoplastic oligopeptidase prediction profiling recurs resected sn supernormal termed thimet transcriptase	125b affliction altering angiogenic anomalously bak1 bak1in continues differentiate downregulates dtl etiology expressions grow hnscc mechanistic meis1 mirna mirnas modes ones qrt seq tp53 tyms unravel unreported upregulates vis
Tagcloud (Intersection) ?