THOP1 and TTC3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		THOP1	TTC3
Description		thimet oligopeptidase 1	tetratricopeptide repeat domain 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Intermembrane Space Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Proteolysis Peptide Metabolic Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)	Eye color traits ( 20463881)
Interacting Genes		10 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2 TTC3	72 interacting genes: AKAP17A AKT1 APP ARID1A ATF7IP ATP2A2 ATP6V0A1 BLOC1S2 CADPS CADPS2 CEP290 CHUK CKAP2 CKAP5 COG4 COPS5 DAAM2 DLEU7 DSP DST EIF4G2 ETS2 EXOC4 FBXO7 FMNL2 FUT8 HARS1 HERC2 HSPB1 IFIT5 JADE2 JAK1 KANSL2 LCOR LRPAP1 MDH1 MIR7-1 MORF4L1 NR1D2 NR1H2 NUFIP1 PAX6 PBX2 PKNOX1 POLG PPFIBP1 PRKDC PSMD7 PSME1 RAI14 SH3BP5 SHROOM2 SMARCA4 SPARCL1 SPTAN1 SPTBN1 STXBP1 TAF1 THOP1 TJP1 TRAF6 TTN UBE2D2 UBE2E3 UBE3A UBR4 USP28 VHL WAC WHAMM XRN2 YWHAE
Entrez ID		7064	7267
HPRD ID		03072	03773
Ensembl ID		ENSG00000172009	ENSG00000182670
Uniprot IDs		P52888	H7BZ57 P53804
PDB IDs		1S4B 2O36
Enriched GO Terms of Interacting Partners?		Calcium-mediated Signaling Positive Regulation Of Cholesterol Metabolic Process Calcium Channel Complex Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Blood Circulation Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Sperm Midpiece Angiotensin Type I Receptor Activity Regulation Of Interleukin-2 Production TORC1 Signaling TORC2 Complex Disassembly Negative Regulation Of TORC1 Signaling Intracellular Signaling Cassette Bradykinin Receptor Binding Positive Regulation Of Signal Transduction Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Contraction Negative Regulation Of TOR Signaling TOR Signaling TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Regulation Of Calcium-mediated Signaling Angiotensin Type II Receptor Activity Intracellular Signal Transduction Phospholipase C-activating Angiotensin-activated Signaling Pathway Renal System Process Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Steroid Metabolic Process Protein Kinase Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Heart Rate Regulation Of Striated Muscle Contraction Regulation Of TORC1 Signaling Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Multicellular Organismal Process Positive Regulation Of Lipid Metabolic Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin	Positive Regulation Of RNA Biosynthetic Process Protein-containing Complex Cytosol Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Protein Polyubiquitination Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Biosynthetic Process Dense Core Granule Exocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle Establishment Of Vesicle Localization Protein K48-linked Ubiquitination Vesicle Localization Ubiquitin-protein Transferase Activity Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Calmodulin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein K11-linked Ubiquitination Organelle Localization Toll-like Receptor 4 Signaling Pathway Regulation Of Autophagy Regulation Of Gene Expression Cell Surface Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Protein Modification Process Regulation Of Metabolic Process Enzyme Binding Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Cadherin Binding Positive Regulation Of Macromolecule Metabolic Process Protein Localization To Cell-cell Junction Secretory Granule Localization Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cellular Response To Stress Nucleoplasm Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Cell Cortex Regulation Of RNA Metabolic Process Golgi To Plasma Membrane Transport Ubiquitin-dependent Protein Catabolic Process Proteasome Complex
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