CRCT1 and KRTAP5-8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CRCT1	KRTAP5-8
Description		cysteine rich C-terminal 1	keratin associated protein 5-8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol Intermediate Filament
	Molecular Function	Protein Binding	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process
Pathways			Keratinization
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 21804549 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Obesity-related traits ( 23251661) Plantar warts ( 28928442)
Interacting Genes		62 interacting genes: AGTRAP ALPP APLP1 CEP126 CHD3 CYP21A2 CYSRT1 EEF1A1 GRN IGSF21 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-8 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1C LCE1D LCE1F LCE2A LCE2B LCE2C LCE3A LCE4A LRIF1 MACO1 MEOX2 NOTCH2NLA NUP62 OIT3 PLSCR4 PTN RGS17 RGS20 SDCBP2 SLC39A7 TGM1 TLE1 TRIM55 TRIM63 VIM VWC2L	6 interacting genes: CRCT1 HHEX LCE1E LCE3A LCE5A WNT11
Entrez ID		54544	57830
HPRD ID		16635	17252
Ensembl ID		ENSG00000169509	ENSG00000241233
Uniprot IDs		Q9UGL9	O75690
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Tissue Development Identical Protein Binding Protein Binding Positive Regulation Of Axon Regeneration	Keratinization Epidermis Development Tissue Development Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of MRNA Export From Nucleus Negative Regulation Of Cytoplasmic Translational Initiation Eukaryotic Initiation Factor 4E Binding Regionalization Secondary Palate Development Notochord Morphogenesis Nephron Tubule Morphogenesis Convergent Extension Involved In Axis Elongation Lung-associated Mesenchyme Development Negative Regulation Of Fibroblast Growth Factor Production Maintenance Of Epithelial Cell Apical/basal Polarity Primary Heart Field Specification Ureteric Bud Morphogenesis Wnt Signaling Pathway, Calcium Modulating Pathway Convergent Extension Cloacal Septation Positive Regulation Of Transforming Growth Factor Beta2 Production Atrial Septum Development Nephric Duct Development Regulation Of Transforming Growth Factor Beta2 Production Heart Field Specification Mesonephric Duct Development Negative Regulation Of Mesenchymal Cell Proliferation Paraxial Mesoderm Formation Secondary Heart Field Specification Maintenance Of Cell Polarity Regulation Of Wnt Signaling Pathway DNA Binding, Bending Somite Development Regulation Of RNA Export From Nucleus Translation Regulator Activity DNA Conformation Change Specification Of Animal Organ Identity Renal Tubule Morphogenesis Neuroendocrine Cell Differentiation Positive Regulation Of Transforming Growth Factor Beta Production Pattern Specification Process Positive Regulation Of Epithelial Cell Apoptotic Process Adrenal Gland Development TBP-class Protein Binding Mesenchymal Cell Proliferation
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