NR2F1 and PHB2

Number of citations of the paper that reports this interaction (PubMedID 15140878)
0

Data Source:
BioGRID (pull down, pull down)

		NR2F1	PHB2
Description		nuclear receptor subfamily 2 group F member 1	prohibitin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Nuclear Matrix Protein-containing Complex Mitochondrial Prohibitin Complex Cell Periphery Inner Mitochondrial Membrane Protein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Nuclear Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Nervous System Development Negative Regulation Of Neuron Projection Development Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Cell Migration Regulation Of Complement Activation Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cytochrome-c Oxidase Activity
Pathways		Nuclear Receptor transcription pathway	Processing of SMDT1 Cellular response to mitochondrial stress
Drugs		beta-Naphthoflavone	Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Adult body size ( 32376654) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical volume ( 32963231) Left–right brain asymmetry ( 33723403) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545)	Glycated hemoglobin levels ( 28898252 34059833) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		27 interacting genes: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 FOXP1 FOXP2 FOXP4 GTF2B HNF4A ISL1 MAP6 MCPH1 NCOA1 NCOA2 NCOA3 NCOR2 NSD1 PFDN1 PHB2 POU2F2 RXRA SP1 THRA UBC	26 interacting genes: AFP AKT1 ANXA1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PRKN PTEN PTMA RNF2 TEAD3 UPF2 VHL
Entrez ID		7025	11331
HPRD ID		00584	17843
Ensembl ID		ENSG00000175745	ENSG00000215021
Uniprot IDs		A0A8V8TQQ6 P10589	A0A7I2V5F0 Q99623
PDB IDs		2EBL	6IQE 8J4I 8RRH
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding Nuclear Receptor Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm DNA-templated Transcription Sequence-specific Double-stranded DNA Binding Negative Regulation Of Metabolic Process DNA Binding Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Estrogen Receptor Binding Transcription Cis-regulatory Region Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Nucleus Nuclear Receptor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Thyroid Hormone Receptor Signaling Pathway TBP-class Protein Binding Positive Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Rhythmic Process Response To Lipid	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Enzyme Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Developmental Process Positive Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Binding Negative Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Protein Lysine Deacetylase Activity Protein Lysine Delactylase Activity Transcription Corepressor Binding Response To Hormone Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Histone Deacetylase Binding Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process
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