NR2F1 and BCL11A

Number of citations of the paper that reports this interaction (PMID 10744719)
57

Data Source:
HPRD (in vitro, two hybrid)

		NR2F1	BCL11A
Gene Name		nuclear receptor subfamily 2, group F, member 1	B-cell CLL/lymphoma 11A (zinc finger protein)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Transcription Corepressor Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Negative Regulation Of Neuron Projection Development Cerebral Cortex Regionalization Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Protein Sumoylation B Cell Differentiation T Cell Differentiation Negative Regulation Of Axon Extension Negative Regulation Of Protein Homooligomerization Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Collateral Sprouting Positive Regulation Of Collateral Sprouting Regulation Of Dendrite Development Negative Regulation Of Dendrite Development
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder ( 22012869) Beta thalassemia/hemoglobin E disease ( 20183929) F-cell distribution ( 21326311 17767159) Fetal hemoglobin levels ( 18245381 20018918) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Mean corpuscular volume ( 19862010) Monocyte early outgrowth colony forming units ( 21493818) Red blood cell traits ( 23222517) Sickle cell anemia (haemolysis) ( 23406172) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		21 interactors: AHR BCL11A BCL11B CBX5 COPS2 EEF1D ESR1 GRIP1 GTF2B HNF4A ISL1 MAP6 NCOA1 NCOA3 NCOR2 NSD1 PFDN1 PHB2 RXRA SP1 THRA	20 interactors: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 GMCL1P1 LMO1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 SIRT1 SUMO1 SUMO2 SUMO3 YME1L1 ZBTB24
Entrez ID		7025	53335
HPRD ID		00584	05949
Ensembl ID		ENSG00000175745	ENSG00000119866
Uniprot IDs		F1DAL7 F1DAL9 P10589	D6W5D9 D9YZV9 Q9H165
PDB IDs		2EBL
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gland Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development System Development DNA-templated Transcription, Initiation Organ Development Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Developmental Process Negative Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Reproductive Process Negative Regulation Of Biosynthetic Process Organ Morphogenesis Developmental Process Involved In Reproduction Response To Steroid Hormone Anatomical Structure Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Mammary Gland Development Cellular Response To Steroid Hormone Stimulus Cellular Response To Hormone Stimulus	Positive Regulation Of Cellular Metabolic Process Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Cellular Senescence Positive Regulation Of Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Aging Negative Regulation Of Cellular Metabolic Process Cell Differentiation Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Senescence Protein Sumoylation Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Steroid Hormone Multicellular Organismal Development Generation Of Neurons Positive Regulation Of Cellular Biosynthetic Process Regulation Of Gene Expression Anatomical Structure Development Neurogenesis System Development Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Organ Development Response To Hormone Protein Modification By Small Protein Conjugation Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Differentiation Forebrain Development Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		advantageous appearing begins coincides comprise embryoid emerge hesc hescs hipsc hipscs irx2 lastly manifested nestin neural neuroectoderm nr2f2 oct4 otx2 pax6 pluripotency precedes primitive pyramidal rosette rosettes serotonergic sox1	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Difference) ?		advantageous appearing begins coincides comprise embryoid emerge hesc hescs hipsc hipscs irx2 lastly manifested nestin neural neuroectoderm nr2f2 oct4 otx2 pax6 pluripotency precedes primitive pyramidal rosette rosettes serotonergic sox1	beadchip cpgs cues enhancers erythroblasts erythroid erythropoiesis fetal globin happen hbf hemoglobin highlighting humanmethylation illumina maps mendelian methylated methylation methylome moves overlap red repress sickle switch tend thalassemia unanticipated
Tagcloud (Intersection) ?