PACSIN2 and TRPV4

Number of citations of the paper that reports this interaction (PubMedID 16627472)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PACSIN2	TRPV4
Description		protein kinase C and casein kinase substrate in neurons 2	transient receptor potential cation channel subfamily V member 4
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Adherens Junction Focal Adhesion Cilium Membrane Nuclear Speck Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Ruffle Membrane Centriolar Satellite Cell Projection Recycling Endosome Membrane Extracellular Exosome Anchoring Junction Glutamatergic Synapse	Endoplasmic Reticulum Cytoplasmic Microtubule Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Membrane Apical Plasma Membrane Lamellipodium Filopodium Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Cell Projection Anchoring Junction
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	Nucleotide Binding Actin Binding Osmosensor Activity Protein Kinase C Binding Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding ATP Binding Microtubule Binding Lipid Binding Stretch-activated, Monoatomic Cation-selective, Calcium Channel Activity Protein Kinase Binding SH2 Domain Binding Identical Protein Binding Alpha-tubulin Binding Metal Ion Binding Beta-tubulin Binding Actin Filament Binding
	Biological Process	Cell Migration Involved In Sprouting Angiogenesis Endocytosis Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Diet Induced Thermogenesis Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Cell Volume Homeostasis Response To Osmotic Stress Hypotonic Response Actin Filament Organization Cell-cell Junction Assembly Positive Regulation Of Cytosolic Calcium Ion Concentration Osmosensory Signaling Pathway Response To Mechanical Stimulus Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Neuron Projection Development Actin Cytoskeleton Organization Vasopressin Secretion Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Interleukin-6 Production Response To Insulin Monoatomic Ion Transmembrane Transport Cellular Response To Heat Hyperosmotic Salinity Response Glucose Homeostasis Positive Regulation Of Vascular Permeability Cortical Microtubule Organization Positive Regulation Of Striated Muscle Contraction Positive Regulation Of JNK Cascade Microtubule Polymerization Regulation Of Response To Osmotic Stress Positive Regulation Of Inflammatory Response Multicellular Organismal-level Water Homeostasis Transmembrane Transport Cartilage Development Involved In Endochondral Bone Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Osmotic Stress Cellular Hypotonic Response Cellular Hypotonic Salinity Response Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Energy Homeostasis Blood Vessel Endothelial Cell Delamination Calcium Ion Import Across Plasma Membrane Calcium Ion Import Into Cytosol Negative Regulation Of Brown Fat Cell Differentiation Regulation Of Aerobic Respiration Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Clathrin-mediated endocytosis	TRP channels High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cannabidiol Butamben Medical Cannabis Nabiximols
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD) TRPV4-related skeletal dysplasias, including: Autosomal dominant brachyolmia; Spondylometaphyseal dysplasia, Kozlowski type (SMDK); Metatropic dysplasia; Spondyloepiphyseal dysplasia, Maroteaux type ; Parastremmatic dysplasia Distal hereditary motor neuropathies (dHMN) TRPV4-related peripheral neuropathies, including: Congenital distal spinal muscular atrophy (CDSMA); Scapuloperoneal spinal muscle atrophy (SPSMA); Hereditary motor and sensory neuropathy type IIC (HMSN IIC)
GWAS		Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Prostate cancer (SNP x SNP interaction) ( 22219177)	Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		18 interacting genes: DNM1 EHD1 EXOSC8 FASLG GSC2 MECOM MEOX2 PACSIN1 PACSIN3 PBX4 POT1 RIC8A SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	14 interacting genes: CALM1 FYN HCK ITCH KRIT1 LCK LYN MAP7 OS9 PACSIN1 PACSIN2 PACSIN3 SRC YES1
Entrez ID		11252	59341
HPRD ID		05390	05667
Ensembl ID		ENSG00000100266	ENSG00000111199
Uniprot IDs		Q6FIA3 Q9UNF0	Q9HBA0
PDB IDs		3ABH 3ACO 3HAJ 3Q0K	4DX1 4DX2 7AA5 8FC7 8FC8 8FC9 8FCA 8FCB 8JU5 8JU6 8JVI 8JVJ 8T1B 8T1C 8T1D 8T1E 8T1F
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Telomere Capping Positive Regulation Of Cellular Component Organization Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Negative Regulation Of Cellular Component Organization Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Import Into Cell Membrane Organization Telomeric D-loop Disassembly Regulation Of Cellular Component Organization Positive Regulation Of Telomere Maintenance Telomeric Loop Disassembly Endocytosis Negative Regulation Of Chromosome Organization Plasma Membrane Tubulation DNA Biosynthetic Process Regulation Of Plasma Membrane Organization Positive Regulation Of Organelle Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Organization Lipid Binding Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Organelle Organization Negative Regulation Of DNA Biosynthetic Process Vesicle Budding From Membrane Clathrin Coat Assembly Involved In Endocytosis Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Chromosome, Telomeric Region Presynaptic Endocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Endosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Presynaptic Endocytic Zone Osmosensor Activity Blood Vessel Endothelial Cell Delamination	Fc-gamma Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus T Cell Costimulation Peptidyl-tyrosine Phosphorylation Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Signaling Receptor Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Transport Negative Regulation Of Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Transmembrane Transporter Binding Ephrin Receptor Signaling Pathway Phospholipase Activator Activity Plasma Membrane Tubulation Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune Response Activation Of Innate Immune Response Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Actin Filament Negative Regulation Of Immune Response Cellular Response To Lectin Cellular Response To Platelet-derived Growth Factor Stimulus Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Platelet-derived Growth Factor Ephrin Receptor Binding Positive Regulation Of T Cell Activation Protein Kinase Activity Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Regulation Of Lymphocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Immune System Process Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Cell Migration
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?