PACSIN2 and WASL

Number of citations of the paper that reports this interaction (PMID 12426380)
49

Data Source:
HPRD (two hybrid)

		PACSIN2	WASL
Gene Name		protein kinase C and casein kinase substrate in neurons 2	Wiskott-Aldrich syndrome-like
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Early Endosome Cytosol Cytoskeleton Caveola Cell-cell Junction Focal Adhesion Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Membrane-bounded Vesicle Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Vesicular Exosome	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Lamellipodium Actin Cap Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Protein Binding Cytoskeletal Protein Binding Identical Protein Binding Phosphatidic Acid Binding	Actin Binding Small GTPase Regulator Activity Protein Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Caveola Assembly Caveolin-mediated Endocytosis Membrane Tubulation	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Complex Assembly Membrane Budding Movement Of Cell Or Subcellular Component Mitotic Nuclear Division Axon Guidance Actin Polymerization Or Depolymerization Response To Bacterium Vesicle Organization Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Nitric Oxide Metabolic Process Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-mediated Endocytosis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Axon guidance DCC mediated attractive signaling EPHB-mediated forward signaling Metabolism of nitric oxide NOSTRIN mediated eNOS trafficking EPH-Ephrin signaling Nephrin interactions eNOS activation and regulation Netrin-1 signaling Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Platelet counts ( 22139419)
Protein-Protein Interactions		12 interactors: DNM1 FASLG MEOX2 PACSIN1 PACSIN3 POT1 SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	47 interactors: ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BAIAP2 CDC42 CTTN DNMBP EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		11252	8976
HPRD ID		05390	05448
Ensembl ID		ENSG00000100266	ENSG00000106299
Uniprot IDs		Q6FIA3 Q9UNF0	O00401
PDB IDs		3ABH 3ACO 3HAJ 3Q0K	2FF3 2LNH 2VCP
Enriched GO Terms of Interacting Partners?		Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Cellular Component Organization Regulation Of Endocytosis Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Telomere Maintenance Endocytosis Negative Regulation Of Telomerase Activity Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Membrane Tubulation Regulation Of Telomerase Activity Regulation Of Vesicle-mediated Transport Positive Regulation Of Organelle Organization Positive Regulation Of Protein Depolymerization Endomembrane System Organization Regulation Of Organelle Organization Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Protein Complex Disassembly Endosome Organization Establishment Of Vesicle Localization Positive Regulation Of Cytoskeleton Organization Synaptic Vesicle Endocytosis Regulation Of Chromosome Organization Vesicle Localization Synaptic Vesicle Recycling Negative Regulation Of Endocytosis Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication DNA Replication Homeostatic Process Actin Filament Organization Vesicle-mediated Transport Establishment Of Organelle Localization Positive Regulation Of Synaptic Vesicle Uncoating Cortical Microtubule Organization Synaptic Vesicle Uncoating Positive Regulation Of DNA Strand Elongation Primary Spermatocyte Growth Osmosensory Signaling Pathway Negative Regulation Of DNA Recombination At Telomere Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Cell-cell Signaling	Endocytosis Vesicle-mediated Transport Actin Filament-based Process Actin Cytoskeleton Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cytoskeleton Organization Cell Projection Morphogenesis Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Part Morphogenesis Neuron Projection Morphogenesis Axon Guidance Fc Receptor Signaling Pathway Axonogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Morphogenesis Positive Regulation Of Cellular Component Biogenesis Axon Development Neuron Projection Development Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Phagocytosis Immune Response-regulating Signaling Pathway Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Chemotaxis Locomotion Actin Filament Organization Innate Immune Response Neuron Differentiation Organelle Organization Positive Regulation Of Protein Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response Positive Regulation Of Actin Filament Polymerization Generation Of Neurons Positive Regulation Of Protein Polymerization Positive Regulation Of Immune System Process Regulation Of Protein Complex Assembly Neurogenesis Regulation Of Actin Cytoskeleton Organization Immune System Process Anatomical Structure Morphogenesis Transport Defense Response Regulation Of Immune Response
Tagcloud ?		abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 stimulatory tail trafficking tubulin	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 stimulatory supporting suppressing unmethylated usf1 vav2
Tagcloud (Difference) ?		abolished apo bidirectional cd178 cd95 cd95l constructs correspond cytosolic fas fbp17 fingerprints formin fragments grb2 homology lysates mediator overexpressed polyproline precipitate precipitates respective sh3 tail trafficking tubulin	148a biomarker biopsies cg consensus consequences downregulated dysregulated ectopic emsa hypermethylation integrin methylated micrornas mir mirna mirnas nasopharyngeal np npc oncogenes pivotal rock1 supporting suppressing unmethylated usf1 vav2
Tagcloud (Intersection) ?		stimulatory