TEP1 and PTPA

Number of citations of the paper that reports this interaction (PubMedID 9837921)
0

Data Source:
BioGRID (enzymatic study)

		TEP1	PTPA
Description		telomerase associated protein 1	protein phosphatase 2 phosphatase activator
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Chromosome Telomerase Holoenzyme Complex Cytoplasm Nuclear Matrix Ribonucleoprotein Complex	Protein Phosphatase Type 2A Complex Nucleus Nucleoplasm Cytoplasm Calcium Channel Complex Extracellular Exosome ATPase Complex
	Molecular Function	Nucleotide Binding P53 Binding Telomerase Activity RNA Binding Protein Binding ATP Binding Enzyme Binding Telomerase RNA Binding	Nucleotide Binding Peptidyl-prolyl Cis-trans Isomerase Activity Phosphoprotein Phosphatase Activity Signaling Receptor Binding Protein Binding ATP Binding Protein Tyrosine Phosphatase Activator Activity Isomerase Activity Phosphatase Activator Activity Protein Phosphatase Regulator Activity Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Protein Phosphatase 2A Binding
	Biological Process	Telomere Maintenance Via Recombination DNA Metabolic Process RNA-templated DNA Biosynthetic Process	Mitotic Spindle Organization Positive Regulation Of Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Food addiction ( 27106561) White matter microstructure in first episode schizophrenia (left anterior cingulate cortex) ( 28924203)
Interacting Genes		9 interacting genes: ATN1 MTDH PRKCA PTPA RHOXF2 RNF10 TERT TP53 UBAP2	32 interacting genes: AKT1 AMOT APP AURKB CCDC125 CCNE1 CCNG1 CCNG2 CSNK2A1 CYLD DTD1 EIF4EBP1 F3 FOXO3 GRIN3A GSK3B H2AX HDAC4 KISS1R MAPT MID1 NIF3L1 PPP2R1A PPP2R3A PRKCB RACGAP1 SGO1 SPG21 SRC SULT4A1 TEP1 TERT
Entrez ID		7011	5524
HPRD ID		03404	02858
Ensembl ID		ENSG00000129566	ENSG00000119383
Uniprot IDs		G3V5X7 Q99973	F6WIT2 Q15257
PDB IDs			2G62 2HV6 2HV7 2IXM 4LAC 4NY3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein Phosphatase 2A Binding Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Replicative Senescence Negative Regulation Of Glial Cell Proliferation Determination Of Adult Lifespan Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Regulation Of Angiogenesis Regulation Of Cellular Senescence TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Transcription Coactivator Binding Positive Regulation Of Transdifferentiation Positive Regulation Of MiRNA Metabolic Process RNA-directed RNA Polymerase Complex Positive Regulation Of MiRNA Transcription SiRNA Transcription Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Gliogenesis Regulation Of Glial Cell Proliferation Regulation Of Vasculature Development Negative Regulation Of Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Tissue Remodeling Negative Regulation Of Programmed Cell Death Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of MiRNA Metabolic Process Regulation Of Stem Cell Proliferation Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Regulation Of Cell Cycle Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cytoplasm Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway TOR Signaling Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Protein Localization Response To Nerve Growth Factor Positive Regulation Of Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Canonical Wnt Signaling Pathway Enzyme Binding Mitotic Cell Cycle Phase Transition Negative Regulation Of Intracellular Signal Transduction Regulation Of TOR Signaling Regulation Of Protein Localization To Nucleus Regulation Of Developmental Process Negative Regulation Of Metabolic Process Regulation Of Cell Motility Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wnt Signaling Pathway Protein Kinase Binding Regulation Of Locomotion Positive Regulation Of Developmental Process Positive Regulation Of TOR Signaling Mitochondrion Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of TOR Signaling Response To Growth Factor
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