TEAD4 and WWTR1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)
HPRD (two hybrid)

		TEAD4	WWTR1
Description		TEA domain transcription factor 4	WW domain containing transcription regulator 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Nuclear Body Anchoring Junction
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Cell Fate Specification Blastocyst Formation Trophectodermal Cell Fate Commitment DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Embryo Implantation Hippo Signaling Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Stem Cell Population Maintenance	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Heart Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly SMAD Protein Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription	Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Narcolepsy with cataplexy ( 23496005)	Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011) Triglyceride levels ( 34074324)
Interacting Genes		50 interacting genes: CCDC125 CCDC172 CCDC85B CCNDBP1 CDR2 CEP55 CEP70 CRYAA CTBP1 DYDC1 EXOC3-AS1 FBXO7 GOLGA2 GOLGA6L9 HAUS1 HOMEZ INCA1 KIAA0753 KRT27 KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MDFI MTUS2 MYH7 NUTM1 PDE4DIP PFKM PNMA1 PRDM14 PRKAR1B RABGEF1 RASSF10 RUNDC3A RUNX1 SAT1 SESTD1 SORBS3 SSX2IP TLE5 TRAF1 TRIM54 VGLL1 VGLL3 VPS52 VTA1 WWTR1 YAP1	21 interacting genes: BTRC C1orf74 DAPK1 IL16 LATS2 MFHAS1 NHERF2 NKX2-1 PAX3 PRRG2 PRRG4 RTN4IP1 RUNX1 SUMO3 TCP11L1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAZ
Entrez ID		7004	25937
HPRD ID		03421	09580
Ensembl ID		ENSG00000197905	ENSG00000018408
Uniprot IDs		Q15561	Q9GZV5
PDB IDs		5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO 8A8R 8C17 8CAA	5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX 8R0Z
Enriched GO Terms of Interacting Partners?		Cytoskeleton Microtubule Organizing Center Organization Centrosome Cycle Centrosome Cytoplasm Cardiac Muscle Tissue Regeneration Protein Binding Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Keratin Filament	Hippo Signaling Intracellular Signal Transduction Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Transcription Regulator Complex Positive Regulation Of Circadian Rhythm Positive Regulation Of Hippo Signaling Negative Regulation Of Immune System Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
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