TEAD4 and MYH7

Number of citations of the paper that reports this interaction (PMID 12861002)
21

Data Source:
HPRD (two hybrid, in vitro)

		TEAD4	MYH7
Gene Name		TEA domain family member 4	myosin, heavy chain 7, cardiac muscle, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Stress Fiber Nucleoplasm Cytoplasm Muscle Myosin Complex Focal Adhesion Myosin Complex Sarcomere Z Disc Myosin Filament
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity
	Biological Process	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Gene Expression Hippo Signaling	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Muscle Contraction Striated Muscle Contraction Adult Heart Development Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS		Narcolepsy with cataplexy ( 23496005)	Resting heart rate ( 20639392)
Protein-Protein Interactions		18 interactors: CCDC172 CCDC85B CCNDBP1 CEP55 CEP70 GOLGA2 KIAA0753 LZTS2 MYH7 PNMA1 RABGEF1 SSX2IP TRAF1 TRIM27 VGLL1 VPS52 WWTR1 YAP1	4 interactors: KXD1 TEAD1 TEAD3 TEAD4
Entrez ID		7004	4625
HPRD ID		03421	01175
Ensembl ID		ENSG00000197905	ENSG00000092054
Uniprot IDs		D3DUQ6 Q15561	P12883
PDB IDs			1IK2 2FXM 2FXO 3DTP 4DB1
Enriched GO Terms of Interacting Partners?		Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Hippo Signaling Negative Regulation Of Protein Transport Negative Regulation Of Cytokine Secretion Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Kit Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Mitotic Cell Cycle Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Interleukin-2 Secretion Embryonic Ectodermal Digestive Tract Development Cell Cycle Regulation Of Protein Localization Negative Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cytokinesis Cell Division Negative Regulation Of Intracellular Transport Regulation Of Fat Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Regulation Of Cytokine Secretion Regulation Of Epithelial Cell Differentiation Negative Regulation Of Calcium Ion Import Negative Regulation Of Mast Cell Activation Involved In Immune Response Intraciliary Transport Involved In Cilium Morphogenesis Ectodermal Cell Differentiation Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Secretion By Cell Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma Secretion Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Ubiquitination Negative Regulation Of Secretion Negative Regulation Of Signaling Regulation Of Signal Transduction Spindle Midzone Assembly Protein Modification By Small Protein Conjugation	Positive Regulation Of Stem Cell Maintenance Regulation Of Stem Cell Maintenance Hippo Signaling Positive Regulation Of Stem Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Cell Development Regulation Of Cell Development Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Female Pregnancy Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Lateral Mesoderm Development Transcription, DNA-templated Notochord Development RNA Biosynthetic Process Trophectodermal Cell Differentiation Paraxial Mesoderm Development Positive Regulation Of Cellular Metabolic Process Blastocyst Formation RNA Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Embryonic Heart Tube Morphogenesis Cellular Macromolecule Biosynthetic Process Embryo Implantation Embryo Development Macromolecule Biosynthetic Process Embryonic Heart Tube Development Cell Fate Specification Blastocyst Development Reproductive Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Mesoderm Development Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1	5188delaga aggregates alert autosomal biopsies cd3 cd68 cd8 comprising contained distal endomysial inclusion k1729del laing member mhc myopathy myositis p62 pathologic perivascular physicians possibility rimmed smi specimen typical vacuoles
Tagcloud (Difference) ?		amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1	5188delaga aggregates alert autosomal biopsies cd3 cd68 cd8 comprising contained distal endomysial inclusion k1729del laing member mhc myopathy myositis p62 pathologic perivascular physicians possibility rimmed smi specimen typical vacuoles
Tagcloud (Intersection) ?