TEAD4 and MYH7

Number of citations: 61 (PubMedID 12861002)
Data Source: HPRD (two hybrid, in vitro)

		TEAD4	MYH7
Name		TEA domain transcription factor 4	myosin heavy chain 7
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-DNA Complex	Stress Fiber Cytoplasm Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Z Disc Myosin Filament Supramolecular Fiber
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Skeletal System Development In Utero Embryonic Development Cell Fate Specification Blastocyst Formation Trophectodermal Cell Fate Commitment DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Embryo Implantation Hippo Signaling Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Stem Cell Population Maintenance	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Zygotic genome activation (ZGA) Regulation of PD-L1(CD274) transcription	None
Drugs		None	4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Mavacamten
Diseases		None	Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM) Myosin storage myopathy (MSM); Hyaline body myopathy Hypertrophic cardiomyopathy (HCM)
GWAS		Narcolepsy with cataplexy ( 23496005 )	Atrial fibrillation ( 29892015 30061737 ) Resting heart rate ( 20639392 27798624 )
Interacting Genes		50 interacting genes: CCDC125 CCDC172 CCDC85B CCNDBP1 CDR2 CEP55 CEP70 CRYAA CTBP1 DYDC1 EXOC3-AS1 FBXO7 GOLGA2 GOLGA6L9 HAUS1 HOMEZ INCA1 KIAA0753 KRT27 KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MDFI MTUS2 MYH7 NUTM1 PDE4DIP PFKM PNMA1 PRDM14 PRKAR1B RABGEF1 RASSF10 RUNDC3A RUNX1 SAT1 SESTD1 SORBS3 SSX2IP TLE5 TRAF1 TRIM54 VGLL1 VGLL3 VPS52 VTA1 WWTR1 YAP1	12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3
Entrez ID		7004	4625
HPRD ID		03421	01175
Ensembl ID		ENSG00000197905	ENSG00000092054
Uniprot IDs		Q15561	P12883
PDB IDs		5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO 8A8R 8C17 8CAA	2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP 8ACT 8EFD 8EFE 8EFH 8EFI 8ENC 8G4L 8ZB7 8ZI9 9GZ1 9GZ2 9GZ3
GO Terms Enriched among Interactors		Cytoskeleton Microtubule Organizing Center Organization Centrosome Cycle Centrosome Cytoplasm Cardiac Muscle Tissue Regeneration Protein Binding Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Keratin Filament	Hippo Signaling Embryonic Organ Development Lysosome Localization Regulation Of Lysosome Size BORC Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane BLOC-1 Complex Regulation Of Vesicle Size Ciliary Base Transcription Regulator Complex Trophectodermal Cell Fate Commitment Positive Regulation Of Late Endosome To Lysosome Transport Lysosome Organization Neuron Cellular Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Animal Organ Development TEAD-YAP Complex Asymmetric Neuroblast Division Intraciliary Transport Particle A Binding Bronchus Morphogenesis Lysosomal Membrane Organelle Transport Along Microtubule Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone