WWTR1 and PLOD2

Data Source: HiPPIP (Novel)

		WWTR1	PLOD2
Name		WW domain containing transcription regulator 1	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Nuclear Body Anchoring Junction	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Rough Endoplasmic Reticulum Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Iron Ion Binding Procollagen-lysine 5-dioxygenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Procollagen Glucosyltransferase Activity Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Heart Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly SMAD Protein Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus	Response To Hypoxia Protein O-linked Glycosylation Peptidyl-lysine Hydroxylation Collagen Fibril Organization Protein Modification Process Hydroxylysine Biosynthetic Process
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription	Collagen biosynthesis and modifying enzymes
Drugs		None	Ascorbic acid
Diseases		None	Bruck syndrome
GWAS		Height ( 31562340 ) Polycystic ovary syndrome ( 32289280 ) Preeclampsia ( 23551011 ) Triglyceride levels ( 34074324 )	Height ( 31562340 ) Obesity-related traits ( 23251661 ) Squamous cell lung carcinoma ( 28604730 ) Zinc levels ( 26025379 )
Novel Interactors		1 novel interactors: PLOD2	6 novel interactors: CENPF CLSTN2 LITAF LYPLA1 NUCB1 WWTR1
Interacting Genes		21 interacting genes: BTRC C1orf74 DAPK1 IL16 LATS2 MFHAS1 NHERF2 NKX2-1 PAX3 PRRG2 PRRG4 RTN4IP1 RUNX1 SUMO3 TCP11L1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAZ	1 interacting genes: LINC01554
Entrez ID		25937	5352
HPRD ID		09580	03519
Ensembl ID		ENSG00000018408	ENSG00000152952
Uniprot IDs		Q9GZV5	A0A994J6S5 O00469
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX 8R0Z	Not available
GO Terms Enriched among Interactors		Hippo Signaling Intracellular Signal Transduction Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Transcription Regulator Complex Positive Regulation Of Circadian Rhythm Positive Regulation Of Hippo Signaling Negative Regulation Of Immune System Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	None