TEAD4 and YAP1

Number of citations of the paper that reports this interaction (PMID 11358867)
99

Data Source:
HPRD (in vitro, in vivo)

		TEAD4	YAP1
Gene Name		TEA domain family member 4	Yes-associated protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Membrane Cell Junction
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Regulatory Region DNA Binding Proline-rich Region Binding
	Biological Process	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Gene Expression Hippo Signaling	Cell Morphogenesis Vasculogenesis Embryonic Heart Tube Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Cell Proliferation Positive Regulation Of Cell Proliferation Gene Expression Regulation Of Keratinocyte Proliferation Keratinocyte Differentiation Negative Regulation Of Epithelial Cell Differentiation Notochord Development Somatic Stem Cell Maintenance Hippo Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Organ Growth Paraxial Mesoderm Development Lateral Mesoderm Development Contact Inhibition Cellular Response To Gamma Radiation Regulation Of Stem Cell Proliferation Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	PPARA activates gene expression Nuclear signaling by ERBB4 Fatty acid, triacylglycerol, and ketone body metabolism Signaling by Hippo Generic Transcription Pathway Metabolism of lipids and lipoproteins YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by ERBB4
Drugs
Diseases
GWAS		Narcolepsy with cataplexy ( 23496005)	MRI atrophy measures ( 21116278) Polycystic ovary syndrome ( 22885925) Prostate cancer ( 23535732) Pubertal anthropometrics ( 23449627)
Protein-Protein Interactions		18 interactors: CCDC172 CCDC85B CCNDBP1 CEP55 CEP70 GOLGA2 KIAA0753 LZTS2 MYH7 PNMA1 RABGEF1 SSX2IP TRAF1 TRIM27 VGLL1 VPS52 WWTR1 YAP1	28 interactors: ABL1 AKT1 BTRC DENND3 ERBB4 HNRNPU KIF5A LATS1 LATS2 NFE2 RUNX1 RUNX2 RUNX3 SCAMP3 SLC9A3R1 SMAD1 SMAD7 TEAD1 TEAD2 TEAD3 TEAD4 TP53BP2 TP63 TP73 WBP1 WBP2 YWHAG YWHAQ
Entrez ID		7004	10413
HPRD ID		03421	09424
Ensembl ID		ENSG00000197905	ENSG00000137693
Uniprot IDs		D3DUQ6 Q15561	K0KVU2 P46937 Q86T74
PDB IDs			1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
Enriched GO Terms of Interacting Partners?		Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Hippo Signaling Negative Regulation Of Protein Transport Negative Regulation Of Cytokine Secretion Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Kit Signaling Pathway Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation Mitotic Cell Cycle Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Interleukin-2 Secretion Embryonic Ectodermal Digestive Tract Development Cell Cycle Regulation Of Protein Localization Negative Regulation Of Protein Secretion Negative Regulation Of Transport Negative Regulation Of Phosphorylation Cytokinesis Cell Division Negative Regulation Of Intracellular Transport Regulation Of Fat Cell Differentiation Negative Regulation Of Immune Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Regulation Of Cytokine Secretion Regulation Of Epithelial Cell Differentiation Negative Regulation Of Calcium Ion Import Negative Regulation Of Mast Cell Activation Involved In Immune Response Intraciliary Transport Involved In Cilium Morphogenesis Ectodermal Cell Differentiation Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Secretion By Cell Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Interferon-gamma Secretion Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Ubiquitination Negative Regulation Of Secretion Negative Regulation Of Signaling Regulation Of Signal Transduction Spindle Midzone Assembly Protein Modification By Small Protein Conjugation	Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Organ Development Positive Regulation Of Gene Expression Intracellular Signal Transduction Positive Regulation Of Cellular Biosynthetic Process System Development Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signal Transduction Developmental Process Anatomical Structure Development Epithelium Development Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Response To Stimulus Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Signaling Regulation Of Metabolic Process Positive Regulation Of Stem Cell Maintenance Negative Regulation Of Phosphorylation Signaling Tissue Development Cell Communication Positive Regulation Of Cell Differentiation Embryo Development Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Transferase Activity Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Anatomical Structure Morphogenesis Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Cell Differentiation Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Gene Expression Response To Organic Substance DNA-templated Transcription, Initiation
Tagcloud ?		amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap yap1	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Difference) ?		amphibian amphibians amputation appendage autonomously biol buds dev dnyap epimorphic hayashi hippo organ outgrowth regenerating regeneration regenerative shallow strictly synchronized tadpole tail terminates vertebrate xenopus yap	alarco albicans balan brefeldin bzip caglr1 cai4 cap1 catrr1 caycf1 cdr1 cdr2 cerulenin cjd21 diamide facilitator fcz flr1 fr2 hyperactive hyperresistant mainville mdr1 nitroquinoline phenanthroline raymond reintroduction talibi transformants
Tagcloud (Intersection) ?		yap1