TRB and CD3E

Number of citations of the paper that reports this interaction (PMID 2138083)
29

Data Source:
HPRD (in vivo)

		TRB	CD3E
Gene Name		T cell receptor beta locus	CD3e molecule, epsilon (CD3-TCR complex)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Immunological Synapse Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function		Transmembrane Signaling Receptor Activity Receptor Signaling Protein Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity T Cell Receptor Binding Protein Heterodimerization Activity
	Biological Process		Positive Regulation Of T Cell Anergy Protein Complex Assembly Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Complex Assembly G-protein Coupled Receptor Signaling Pathway Response To Nutrient T Cell Costimulation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Negative Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Apoptotic Signaling Pathway
Pathways			TCR signaling Downstream TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Costimulation by the CD28 family PD-1 signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs			Muromonab
Diseases
GWAS
Protein-Protein Interactions		15 interactors: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 NCOR1 TAF1B TRA TRAT1 TRD	19 interactors: CD3D CD3EAP CD3G CD79B CSK LCK NCK1 NCK2 NCL PIK3R1 PTPN22 SHC1 SNTA1 SYK TOP2B TRAT1 TRB UNC119 ZAP70
Entrez ID		6957	916
HPRD ID		01739	08923
Ensembl ID			ENSG00000198851
Uniprot IDs			P07766
PDB IDs			1A81 1SY6 1XIW 2ROL
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Detection Of Bacterium T Cell Costimulation Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Detection Of Biotic Stimulus Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Endogenous Antigen Innate Immune Response Immune Response-regulating Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity T Cell Differentiation Immune Response T Cell Selection Lymphocyte Activation Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Cell Surface Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Antigen Processing And Presentation Lymphocyte Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Anergy Regulation Of Interferon-gamma Production Hemopoiesis Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma	Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Cell Activation Positive Regulation Of Cell Activation Regulation Of Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Immune System Process Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Innate Immune Response T Cell Costimulation Cell Migration Cell Motility Immune Response Regulation Of Cellular Amino Acid Metabolic Process Lymphocyte Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cellular Ketone Metabolic Process Signal Transduction Cell Adhesion T Cell Differentiation Locomotion Positive Regulation Of Signal Transduction
Tagcloud ?		cdr3 clonotypes complementarity detailed effusion expansive extrapulmonary families firstly illumina manifestation mononuclear oligoclonal pbmcs peaks pemcs platform pleural pltb profiled repertoire sequenced skewed spectratyping tcr throughput trbj1 trbv trbv20	acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Difference) ?		cdr3 clonotypes complementarity detailed effusion expansive extrapulmonary families firstly illumina manifestation mononuclear oligoclonal pbmcs peaks pemcs platform pleural pltb profiled repertoire sequenced skewed spectratyping tcr throughput trbj1 trbv trbv20	acp5 b220 calcitonin calcr cd11b cd2 cd31 cd45 cd5 ctsk dcstamp dentin dihydroxyvitamin dmp1 facs gfp gr1 haematopoietic lin mepe oscar osteocyte osteocytes resolve sclerostin sost tartrate ter119 tnfsf11
Tagcloud (Intersection) ?