TRB and HLA-B

Number of citations of the paper that reports this interaction (PMID 12530975)
83

Data Source:
HPRD (in vitro)

		TRB	HLA-B
Gene Name		T cell receptor beta locus	major histocompatibility complex, class I, B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function		Receptor Binding Peptide Antigen Binding TAP Binding Chaperone Binding
	Biological Process		Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Innate Immune Response Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation
Pathways			Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System
Drugs
Diseases
GWAS			Ankylosing spondylitis ( 21743469) Beta-2 microglubulin plasma levels ( 23417110) CD4:CD8 lymphocyte ratio ( 20045101) Cervical cancer ( 23482656) Drug-induced liver injury (flucloxacillin) ( 19483685) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Graves' disease ( 21841780) Height ( 19343178 23563607) HIV-1 control ( 20205591 21051598 20041166) Hypothyroidism ( 22493691) Multiple sclerosis ( 22190364 19525953) Nasopharyngeal carcinoma ( 20512145) Platelet counts ( 22139419) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 21738480)
Protein-Protein Interactions		15 interactors: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 NCOR1 TAF1B TRA TRAT1 TRD	16 interactors: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3
Entrez ID		6957	3106
HPRD ID		01739	00828
Ensembl ID			ENSG00000234745
Uniprot IDs			E5FQ95 P01889 P30466 S6AU73
PDB IDs			3VCL 4JQV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion T Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune System Process Detection Of Bacterium T Cell Costimulation Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Detection Of Biotic Stimulus Regulation Of Cell Activation Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Processing And Presentation Of Endogenous Antigen Innate Immune Response Immune Response-regulating Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Protection From Natural Killer Cell Mediated Cytotoxicity T Cell Differentiation Immune Response T Cell Selection Lymphocyte Activation Defense Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Leukocyte Activation Cell Surface Receptor Signaling Pathway Single Organismal Cell-cell Adhesion Antigen Processing And Presentation Lymphocyte Differentiation Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Anergy Regulation Of Interferon-gamma Production Hemopoiesis Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cellular Response To Interferon-gamma	Immune Response Regulation Of Immune Response Regulation Of Immune System Process Defense Response Immune System Process Innate Immune Response Leukocyte Differentiation Response To Molecule Of Bacterial Origin Cell Activation Cellular Response To Lipopolysaccharide Response To Other Organism Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Molecule Of Bacterial Origin Response To Biotic Stimulus Response To Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Response To Bacterium Immune Response-inhibiting Signal Transduction Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Dendritic Cell Differentiation Signal Transduction Cell Surface Receptor Signaling Pathway Response To Virus Hemopoiesis Signaling Response To Lipopolysaccharide Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune System Development Cellular Response To Organic Substance Positive Regulation Of Cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Lymphocyte Activation Cellular Response To Lipid Defense Response To Virus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Immune System Process Response To Stimulus Immune Response-regulating Signaling Pathway Tissue Homeostasis Negative Regulation Of Cell Adhesion Viral Process Positive Regulation Of T Cell Activation Cellular Response To Insulin Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion
Tagcloud ?		cdr3 clonotypes complementarity detailed effusion expansive extrapulmonary families firstly illumina manifestation mononuclear oligoclonal pbmcs peaks pemcs platform pleural pltb profiled repertoire sequenced skewed spectratyping tcr throughput trbj1 trbv trbv20
Tagcloud (Difference) ?		cdr3 clonotypes complementarity detailed effusion expansive extrapulmonary families firstly illumina manifestation mononuclear oligoclonal pbmcs peaks pemcs platform pleural pltb profiled repertoire sequenced skewed spectratyping tcr throughput trbj1 trbv trbv20
Tagcloud (Intersection) ?