TRB and CD3D

Number of citations of the paper that reports this interaction (PubMedID 2138083)
0

Data Source:
HPRD (in vivo)

		TRB	CD3D
Description		T cell receptor beta locus	CD3 delta subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Signaling Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Surface Receptor Signaling Pathway	Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Muromonab Blinatumomab Teclistamab Odronextamab
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Narcolepsy ( 24204295)	Pulse pressure ( 27841878)
Interacting Genes		14 interacting genes: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 TAF1B TRA TRAT1 TRD	12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB
Entrez ID		6957	915
HPRD ID		01739	01730
Ensembl ID			ENSG00000167286
Uniprot IDs			B0YIY4 P04234
PDB IDs			1XIW 6JXR 7FJD 7FJE 7FJF 7PHR 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Detection Of Biotic Stimulus Detection Of Bacterium T Cell Receptor Binding T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Gamma-delta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response External Side Of Plasma Membrane Antigen Processing And Presentation Of Endogenous Antigen T Cell Selection Regulation Of Immune Response Alpha-beta T Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Cytotoxicity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive T Cell Selection Immune Response-activating Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Immune Response-regulating Signaling Pathway Gamma-delta T Cell Activation Activation Of Immune Response Thymic T Cell Selection Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Detection Of Stimulus Regulation Of T Cell Mediated Immunity Lumenal Side Of Endoplasmic Reticulum Membrane TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains T Cell Activation Peptide Antigen Binding Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Antigen Protection From Natural Killer Cell Mediated Cytotoxicity Response To Bacterium Regulation Of T Cell Proliferation Immune Response To Tumor Cell	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Gamma-delta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Detection Of Tumor Cell Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target T Cell Mediated Immunity Immune Response-activating Signaling Pathway Immune Response Immune Response-regulating Signaling Pathway Activation Of Immune Response Lymphocyte Activation Immune Response To Tumor Cell Membrane Leukocyte Activation Positive Thymic T Cell Selection T Cell Receptor Binding Alpha-beta T Cell Activation Positive T Cell Selection Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Immune Response Lymphocyte Mediated Immunity MHC Class I Protein Binding T Cell Mediated Cytotoxicity Immune System Process Thymic T Cell Selection Protein-containing Complex Assembly Endoplasmic Reticulum Quality Control Compartment Leukocyte Mediated Immunity Protein-containing Complex Organization T Cell Selection Protein Targeting To ER Clathrin-dependent Endocytosis Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Immune Response Synaptic Vesicle Endocytosis Positive Regulation Of Immune System Process Presynaptic Endocytosis Transmembrane Signaling Receptor Activity Plasma Membrane Protein Complex Oligomerization
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