TRB and TRAT1

Number of citations: 36 (PubMedID 11390434)
Data Source: HPRD (in vivo)

		TRB	TRAT1
Name		T cell receptor beta locus	T cell receptor associated transmembrane adaptor 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Plasma Membrane Membrane Centriolar Satellite T Cell Receptor Complex Mitotic Spindle
	Molecular Function	Signaling Receptor Activity	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Detection Of Tumor Cell Immune System Process T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Cell Surface Receptor Signaling Pathway	Negative Regulation Of Receptor Recycling Adaptive Immune Response Immune System Process Cellular Defense Response Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Transport
Pathways		None	PIP3 activates AKT signaling Downstream TCR signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GWAS		Narcolepsy ( 24204295 )	Autoimmune thyroid disease ( 32581359 )
Interacting Genes		14 interacting genes: CD1D CD247 CD3D CD3E CD3G CTCF HLA-A HLA-B HLA-DRB1 NCOA6 TAF1B TRA TRAT1 TRD	13 interacting genes: BDKRB1 CD247 CD3E FYN GRB2 LCK LCP2 LYN PIK3R1 SEC22A SRC TRA TRB
Entrez ID		6957	50852
HPRD ID		01739	05392
Ensembl ID		Not available	ENSG00000163519
Uniprot IDs		Not available	C9JF66 Q6PIZ9
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Alpha-beta T Cell Receptor Complex Adaptive Immune Response T Cell Receptor Complex Detection Of Biotic Stimulus Detection Of Bacterium T Cell Receptor Binding T Cell Receptor Signaling Pathway Positive Regulation Of Immune Response Gamma-delta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response External Side Of Plasma Membrane Antigen Processing And Presentation Of Endogenous Antigen T Cell Selection Regulation Of Immune Response Alpha-beta T Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Cytotoxicity Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Immune System Process Positive Regulation Of Leukocyte Mediated Cytotoxicity Positive T Cell Selection Immune Response-activating Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Immune Response-regulating Signaling Pathway Gamma-delta T Cell Activation Activation Of Immune Response Thymic T Cell Selection Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Detection Of Stimulus Regulation Of T Cell Mediated Immunity Lumenal Side Of Endoplasmic Reticulum Membrane TAP Binding T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains T Cell Activation Peptide Antigen Binding Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Antigen Processing And Presentation Of Exogenous Antigen Protection From Natural Killer Cell Mediated Cytotoxicity Response To Bacterium Regulation Of T Cell Proliferation Immune Response To Tumor Cell	T Cell Costimulation Immune Response-activating Cell Surface Receptor Signaling Pathway Alpha-beta T Cell Receptor Complex Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Fc-gamma Receptor Signaling Pathway Immune Response-activating Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway T Cell Receptor Complex Immune System Process Regulation Of Immune Response Cell-cell Junction Ephrin Receptor Binding Enzyme-linked Receptor Protein Signaling Pathway Immune Effector Process Positive Regulation Of Immune Response Regulation Of Immune System Process T Cell Receptor Signaling Pathway Lymphocyte Activation Positive Regulation Of T Cell Activation Immune Response Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Leukocyte Cell-cell Adhesion Adaptive Immune Response T Cell Activation Peptidyl-tyrosine Phosphorylation Phospholipase Activator Activity T Cell Receptor Binding Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Phosphatidylinositol 3-kinase Binding Leukocyte Mediated Cytotoxicity Gamma-delta T Cell Activation Stimulatory C-type Lectin Receptor Signaling Pathway Phospholipase Binding Cellular Response To Lectin Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Leukocyte Migration Detection Of Tumor Cell Regulation Of Cell Adhesion