KDM5A

Gene Name		lysine (K)-specific demethylase 5A
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors
	Biological Process	Chromatin Organization Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Chromatin Modification Circadian Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process Negative Regulation Of Histone Deacetylase Activity
Pathways		Chromatin modifying enzymes Chromatin organization HDMs demethylate histones
Drugs
Diseases
GWAS
Protein-protein Interactions		10 interactors: ESR1 HIST2H3A HIST3H3 LMO2 NR3C1 RARA RB1 RBL1 TBP VDR
Entrez ID		5927
HPRD ID		08915
Ensembl ID		ENSG00000073614
Uniprot IDs		P29375
PDB IDs		2JXJ 2KGG 2KGI 3GL6
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Positive Regulation Of Transcription, DNA-templated Intracellular Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Regulation Of Lipid Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Hormone-mediated Signaling Pathway Cellular Nitrogen Compound Metabolic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Mammary Gland Branching Involved In Pregnancy Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Kinase Activity Mammary Gland Duct Morphogenesis Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To Hormone Stimulus Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Mammary Gland Morphogenesis Tube Development Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Mammary Gland Epithelium Development Multicellular Organismal Reproductive Process Cellular Macromolecule Biosynthetic Process Multicellular Organism Reproduction Macromolecule Biosynthetic Process Epithelial Tube Morphogenesis Cellular Response To Organic Cyclic Compound
Tagcloud ?		blast blastic bp called cml demethylase demethylating downregulated epigenetically fatal h3k4 inhibits jarid1a leukemia locus lysine mir myeloid pdcd4 poorly rbp2 responds stimulates transformation treatments trimethylated turn underexpressed usually