KDM5A

Description		lysine demethylase 5A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Protein-DNA Complex
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Enzyme Inhibitor Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Histone H3K4 Demethylase Activity Histone H3K4me/H3K4me2/H3K4me3 Demethylase Activity Histone Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Circadian Regulation Of Gene Expression Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Facultative Heterochromatin Formation
Pathways		HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS		Body mass index ( 26426971) Pulse pressure ( 27841878) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Novel Interacting Genes		1 novel interacting genes: PKP2
Interacting Genes		14 interacting genes: CCT6A DSCR9 ESR1 H3-4 H3C1 H3C15 LMO2 NR3C1 RARA RB1 RBL1 RNF10 TBP VDR
Entrez ID		5927
HPRD ID		08915
Ensembl ID		ENSG00000073614
Uniprot IDs		P29375
PDB IDs		2JXJ 2KGG 2KGI 3GL6 5C11 5CEH 5E6H 5ISL 5IVB 5IVC 5IVE 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF 5K4L 5V9P 5V9T 6BGU 6BGV 6BGW 6BGX 6BGY 6BGZ 6BH0 6BH1 6BH2 6BH3 6BH4 6BH5 6DQ4 6DQ5 6DQ6 6DQ7 6DQ8 6DQ9 6DQA 6DQB 6DQC 6DQD 6DQE 6DQF 7KLO 7KLR
Enriched GO Terms of Interacting Partners?		DNA Binding Nuclear Receptor Activity Protein-DNA Complex Assembly Chromatin Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway TFIIB-class Transcription Factor Binding Mammary Gland Branching Involved In Pregnancy Transcription By RNA Polymerase II Chromatin Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Lipid Kinase Activity Nucleoplasm Regulation Of Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Transcription DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Estrogen Response Element Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Structural Constituent Of Chromatin Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Cellular Response To Estrogen Stimulus Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Core Promoter Sequence-specific DNA Binding Nucleosome Assembly Branching Involved In Mammary Gland Duct Morphogenesis Nucleosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity
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