FOS and PSMA3

Number of citations of the paper that reports this interaction (PubMedID 36291102)
57

Data Source:
BioGRID (pull down)

		FOS	PSMA3
Description		Fos proto-oncogene, AP-1 transcription factor subunit	proteasome 20S subunit alpha 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endoplasmic Reticulum Cytosol Nuclear Matrix Protein-DNA Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Conditioned Taste Aversion Neural Retina Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Response To Xenobiotic Stimulus Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Regulation Of Gene Expression Response To Activity Skeletal Muscle Cell Proliferation Cerebral Cortex Development Neuron Differentiation Osteoclast Differentiation Response To Lipopolysaccharide Response To Progesterone Response To Insulin Cellular Response To Hormone Stimulus Response To Cytokine Cellular Response To Zinc Ion Starvation Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Response To Corticosterone Myoblast Proliferation Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Medium-term Memory Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation Response To Forskolin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Prolactin	Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling NPAS4 regulates expression of target genes Regulation of PD-L1(CD274) transcription	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		Pseudoephedrine Nandrolone decanoate Nadroparin	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)	Brain morphology (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 32888494)
Interacting Genes		126 interacting genes: AKAP5 ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCDC120 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L EEF1D ELK1 ELK4 ENKD1 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HMGB1 HNF1A HNRNPD HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MDM2 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFIA NFIB NFIC NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PRKAR2A PSMA3 PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TENT5B TP53 TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133	120 interacting genes: ADGRL1 APLN ATN1 ATP6V0C AURKB BTN2A2 BTRC C1orf105 CCDC69 CCL28 CDK6 CDKN1A CEBPA CIP2A CRB3 CRYAB CSNK2A1 CST2 CTBP1-DT CYBA DDX5 DGLUCY DMC1 DMRT3 DVL1 EGR1 FAM171A2 FAM218A FAM83A FBXL18 FNDC3B FOS FRAT1 GATA2 GATA3 GFI1B GORASP2 HHEX HSPB1 IKBKG ILF3 IQCE KIF1A KIRREL2 KIRREL3-AS3 KRAS KRTAP19-5 KRTAP26-1 KRTAP8-1 LASP1 LBP LETM1 LINC00908 LINC02913 MDM2 MIA2 NEU4 NOL4L-DT NPBWR2 NPPB NUMBL OLIG2 OSR2 PATL1 PCOTH PLK1 PML POMP PRELID3A PRNP PRR13 PRR3 PRRC2A PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB10 PSMB5 PTPN23 PWWP2B PWWP3A RAB3IL1 RAD54L2 RAMAC RBFOX2 RERE RFT1 RTP5 RUSC1-AS1 SERF2 SF1 SH3KBP1 SLAIN1 SLC22A23 SNRPB SNRPC SNRPF SPATA8 SRPK2 STUB1 STX11 STX1A STX4 STX6 TBC1D16 TBX6 TCF7L2 TINCR TP53 TRIB3 UBD URB1-AS1 VPS37C XRN2 YPEL3 ZNF366 ZNF385C ZNF688
Entrez ID		2353	5684
HPRD ID		01275	01463
Ensembl ID		ENSG00000170345	ENSG00000100567
Uniprot IDs		P01100 Q6FG41	A0A140VK43 P25788
PDB IDs		1A02 1FOS 1S9K	4R3O 4R67 5A0Q 5DSV 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7E55 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-templated Transcription Transcription Regulator Complex Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Programmed Cell Death Regulation Of Cell Differentiation Sequence-specific DNA Binding Positive Regulation Of Gene Expression Regulation Of Apoptotic Process Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Response To Gamma Radiation Proteasome Complex Cellular Response To Gamma Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Response To Ionizing Radiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin-dependent Protein Catabolic Process Protein Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Gravity Cellular Response To Ionizing Radiation Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Molecular Function Activator Activity Macromolecule Catabolic Process Negative Regulation Of Cell Cycle Nuclear Matrix Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Protein Destabilization Regulation Of Protein Stability HMG Box Domain Binding Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Hormone Metabolic Process Protein Catabolic Process Negative Regulation Of Macromolecule Metabolic Process SNAP Receptor Activity Proteasomal Protein Catabolic Process Cellular Response To Actinomycin D Promoter-specific Chromatin Binding Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Senescence
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