KLF5 and GTF2F1

Number of citations of the paper that reports this interaction (PMID 9089417)
4

Data Source:
BioGRID (pull down)

		KLF5	GTF2F1
Gene Name		Kruppel-like factor 5 (intestinal)	general transcription factor IIF, polypeptide 1, 74kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Cell Junction
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Metal Ion Binding	DNA Binding Transcription Coactivator Activity Catalytic Activity Protein Binding Transcription Factor Binding Phosphatase Activator Activity Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Intestinal Epithelial Cell Development Cellular Response To Organic Cyclic Compound Cellular Response To Peptide	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Response To Virus Gene Expression Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Catalytic Activity Positive Regulation Of Viral Transcription
Pathways		Transcriptional regulation of white adipocyte differentiation	RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Influenza Life Cycle HIV elongation arrest and recovery HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Influenza Viral RNA Transcription and Replication RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Pancreatic cancer ( 20101243)
Protein-Protein Interactions		18 interactors: CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HDAC1 NFKB1 PRKCA PRKCD RARA SET SMURF2 TBP WWP1	31 interactors: ABL1 AHR AR ARNT ATF7IP CCNT1 CDK9 CSNK2A1 CTDP1 CTDSP1 FCP1 FEZ1 FOS GTF2A1 GTF2B GTF2E2 GTF2F2 GTF2H4 JUN KLF5 MAGEC1 MSX2 MYC PARP1 PSMC2 PTN SRF TAF1 TAF11 TBP TRIM27
Entrez ID		688	2962
HPRD ID		04212	01803
Ensembl ID		ENSG00000102554	ENSG00000125651
Uniprot IDs		A2TJX0 Q13887 Q5T6X2	P35269
PDB IDs		2EBT	1F3U 1I27 1J2X 1NHA 1ONV 2K7L
Enriched GO Terms of Interacting Partners?		Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Regulation Of Nitrogen Compound Metabolic Process Viral Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process DNA-templated Transcription, Elongation Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Cellular Nitrogen Compound Metabolic Process Neurotrophin Signaling Pathway Regulation Of Cell Death Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Transcription, DNA-templated DNA-templated Transcription, Elongation RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Gene Expression DNA-templated Transcription, Initiation RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Viral Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Viral Transcription Regulation Of Nucleic Acid-templated Transcription Viral Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Viral Process Regulation Of Viral Process Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cellular Component Organization Negative Regulation Of Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Cell Proliferation
Tagcloud ?		3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator regulators smad7 stat3 suppressed tgf	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		3t3 activities adipocyte adipocytes adipogenesis adipogenic ampk ap2 atorvastatin attractive cascades combination diseases ebpalpha elevated excessive exerts homeostasis l1 master metformin obesity ppargamma regulator regulators smad7 stat3 suppressed tgf	akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?