TAF4 and CBX3

Number of citations of the paper that reports this interaction (PubMedID 11959914)
60

Data Source:
HPRD (two hybrid, in vitro)

		TAF4	CBX3
Description		TATA-box binding protein associated factor 4	chromobox 3
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GO Annotations	Cellular Component	Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Cytosol Protein-containing Complex Transcription Factor TFTC Complex MLL1 Complex	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Euchromatin Heterochromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Pericentric Heterochromatin Spindle Senescence-associated Heterochromatin Focus Chromatin Lock Complex RNA Polymerase II Transcription Regulator Complex Site Of DNA Damage
	Molecular Function	Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Aryl Hydrocarbon Receptor Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Coregulator Binding Chromatin Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Ovarian Follicle Development Regulation Of DNA Repair DNA-templated Transcription DNA-templated Transcription Initiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II	Chromatin Organization Chromatin Remodeling DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Dexamethasone Stimulus
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Body mass index ( 28892062) Fasting glucose ( 33381925) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Response to fenofibrate (LDL cholesterol levels) ( 27002377)	Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: AHR ATF7 CBX3 CBX5 CREM GTF2A1 GTF2A2 H3-4 HTT JUN SP1 TAF1 TAF10 TAF11 TAF12 TAF2 TAF5 TAF6 TAF7 TAF8 TAF9 TCF12	42 interacting genes: ADAMTSL4 ADNP2 ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 CDC42 DNMT3B DSN1 GDF15 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 HTR2C KLF11 L3MBTL1 LAP3 LBR LIG1 MGA MIS12 MKI67 MRPL12 NSD3 PIM1 RAD54L2 SP100 STK16 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF280D ZNF496
Entrez ID		6874	11335
HPRD ID		11797	05130
Ensembl ID		ENSG00000130699	ENSG00000122565
Uniprot IDs		O00268	A4D177 B8ZZ43 Q13185
PDB IDs		1H3O 2P6V 6MZC 6MZD 6MZL 6MZM 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGG 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	2L11 3DM1 3KUP 3TZD 5T1I 6HW2 8JZW
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIID Complex RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation RNA Polymerase II Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Initiation Transcription Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Initiation MRNA Transcription By RNA Polymerase II Protein-DNA Complex Assembly MRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Transcription Factor TFTC Complex Transcription By RNA Polymerase II Protein Heterodimerization Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process TBP-class Protein Binding Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Nucleus Protein-containing Complex Assembly Regulation Of Gene Expression Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Regulation Of Primary Metabolic Process Protein-containing Complex Organization Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA Repair Regulation Of Macromolecule Metabolic Process SAGA Complex RNA Metabolic Process RNA Polymerase II General Transcription Initiation Factor Binding MLL1 Complex	Chromatin Remodeling Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleus Regulation Of RNA Metabolic Process DNA Binding Heterochromatin Regulation Of Mitotic Cell Cycle Chromo Shadow Domain Binding Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Chromocenter Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Nuclear Division Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Heterochromatin Formation Regulation Of Nuclear Division Nuclear Body Regulation Of Cell Cycle Spindle Midzone MIS12/MIND Type Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Kinetochore Chromosome, Centromeric Region Regulation Of Cell Cycle Process Structural Constituent Of Chromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Protein-containing Complex Chromosome Passenger Complex Attachment Of Spindle Microtubules To Kinetochore Protein-DNA Complex Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleosome Assembly Negative Regulation Of Protein Export From Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Protein Heterodimerization Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process
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