TAF1 and UBTF

Number of citations of the paper that reports this interaction (PubMedID 12498690)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TAF1	UBTF
Description		TATA-box binding protein associated factor 1	upstream binding transcription factor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleotide Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding DNA Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Protein-lysine-acetyltransferase Activity Protein Serine Kinase Activity Histone H4K16ac Reader Activity Transcription Regulator Inhibitor Activity Histone Reader Activity Acetyl-CoA Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Chromatin Organization Chromatin Remodeling DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Negative Regulation Of Gene Expression Midbrain Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To ATP Positive Regulation Of Androgen Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		65 interacting genes: APC APP AR ASF1A ASF1B BRMS1 BRWD1 BTG3 CCNA2 CCND1 CDC42BPA CFAP298 CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GATD3 GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 HUNK ITGB5 JUN LCOR LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 TTC3 UBE2I UBTF	37 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CEBPA CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RNF10 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 USP7 ZMYM2
Entrez ID		6872	7343
HPRD ID		02436	02814
Ensembl ID		ENSG00000147133	ENSG00000108312
Uniprot IDs		A0A804HIC2 P21675	P17480
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 7JJG 7JJH 7JSP 7JTC 7K03 7K0D 7K0U 7K1P 7K27 7K3O 7K42 7K6F 7L6X 7LB0 7LB1 7LB2 7LB3 7N42 7P4S 7T2I 7T36 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIID Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm Transcription Preinitiation Complex Assembly DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly MRNA Transcription Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Factor TFTC Complex DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein-containing Complex Assembly Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Promoter-specific Chromatin Binding Protein Heterodimerization Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Cellular Component Assembly	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase Transcription Factor SL1 Complex Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transcription Initiation At RNA Polymerase I Promoter Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process RNA Polymerase I Preinitiation Complex Assembly Regulation Of Proteolysis RNA Metabolic Process RNA Polymerase I Transcription Regulator Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Gland Development DNA-binding Transcription Factor Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
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