TAF1 and FOS

Number of citations of the paper that reports this interaction (PubMedID 8065335)
50

Data Source:
HPRD (in vitro, in vivo)

		TAF1	FOS
Description		TATA-box binding protein associated factor 1	Fos proto-oncogene, AP-1 transcription factor subunit
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Endoplasmic Reticulum Cytosol Nuclear Matrix Protein-DNA Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding DNA Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Protein-lysine-acetyltransferase Activity Protein Serine Kinase Activity Histone H4K16ac Reader Activity Transcription Regulator Inhibitor Activity Histone Reader Activity Acetyl-CoA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Chromatin Organization Chromatin Remodeling DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Negative Regulation Of Gene Expression Midbrain Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To ATP Positive Regulation Of Androgen Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Conditioned Taste Aversion Neural Retina Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Response To Xenobiotic Stimulus Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Regulation Of Gene Expression Response To Activity Skeletal Muscle Cell Proliferation Cerebral Cortex Development Neuron Differentiation Osteoclast Differentiation Response To Lipopolysaccharide Response To Progesterone Response To Insulin Cellular Response To Hormone Stimulus Response To Cytokine Cellular Response To Zinc Ion Starvation Cellular Response To Reactive Oxygen Species Response To Immobilization Stress Skeletal Muscle Cell Differentiation Response To Muscle Stretch Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Steroid Hormone Response To Corticosterone Myoblast Proliferation Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus Medium-term Memory Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation Response To Forskolin Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Prolactin
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Estrogen-dependent nuclear events downstream of ESR-membrane signaling NPAS4 regulates expression of target genes Regulation of PD-L1(CD274) transcription
Drugs			Pseudoephedrine Nandrolone decanoate Nadroparin
Diseases
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Interacting Genes		65 interacting genes: APC APP AR ASF1A ASF1B BRMS1 BRWD1 BTG3 CCNA2 CCND1 CDC42BPA CFAP298 CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GATD3 GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 HUNK ITGB5 JUN LCOR LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 TTC3 UBE2I UBTF	126 interacting genes: AKAP5 ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5ME BATF BCL3 CABP1 CARM1 CCDC120 CCND1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CSNK2A1 CSNK2A2 CYTH4 DDIT3 DNMT3L EEF1D ELK1 ELK4 ENKD1 EPHB2 ETS1 ETS2 FHL3 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HMGB1 HNF1A HNRNPD HSPA1A JUN JUNB JUND KDM2A KDM2B LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK3 MAPK7 MDM2 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFIA NFIB NFIC NFKB1 OPTN PIN1 PML POLR2E PRKAA2 PRKACA PRKAR2A PSMA3 PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TENT5B TP53 TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		6872	2353
HPRD ID		02436	01275
Ensembl ID		ENSG00000147133	ENSG00000170345
Uniprot IDs		A0A804HIC2 P21675	P01100 Q6FG41
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 7JJG 7JJH 7JSP 7JTC 7K03 7K0D 7K0U 7K1P 7K27 7K3O 7K42 7K6F 7L6X 7LB0 7LB1 7LB2 7LB3 7N42 7P4S 7T2I 7T36 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?		Transcription Factor TFIID Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm Transcription Preinitiation Complex Assembly DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly MRNA Transcription Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Factor TFTC Complex DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein-containing Complex Assembly Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Promoter-specific Chromatin Binding Protein Heterodimerization Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Cellular Component Assembly	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Nucleus Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-templated Transcription Transcription Regulator Complex Intracellular Signal Transduction Sequence-specific Double-stranded DNA Binding Regulation Of Programmed Cell Death Regulation Of Cell Differentiation Sequence-specific DNA Binding Positive Regulation Of Gene Expression Regulation Of Apoptotic Process Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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