TAF1 and MAX

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		TAF1	MAX
Name		TATA-box binding protein associated factor 1	MYC associated factor X
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Chromatin Nucleus Nucleoplasm Dendrite Protein-DNA Complex Cell Projection Mad-Max Complex MLL1 Complex Myc-Max Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II General Transcription Initiation Factor Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding DNA Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity Transferase Activity Acyltransferase Activity Nuclear Receptor Binding TBP-class Protein Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Histone H3K27me3 Reader Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Protein-lysine-acetyltransferase Activity Protein Serine Kinase Activity Histone H4K16ac Reader Activity Transcription Regulator Inhibitor Activity Histone Reader Activity Acetyl-CoA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein Dimerization Activity E-box Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Chromatin Organization Chromatin Remodeling DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Negative Regulation Of Gene Expression Midbrain Development Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To ATP Positive Regulation Of Androgen Receptor Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6
GWAS		No GWAS studies recorded	Anthropometric traits ( 19260139 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Blood trace element (Zn levels) ( 23720494 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular hemoglobin concentration ( 29403010 27863252 32888494 ) Mean corpuscular volume ( 27863252 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil count ( 32888494 ) Obesity-related traits ( 23251661 ) Platelet count ( 32888494 27863252 ) Red blood cell count ( 27863252 32888494 ) Red blood cell traits ( 23222517 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) White blood cell count ( 32888494 )
Interacting Genes		65 interacting genes: APC APP AR ASF1A ASF1B BRMS1 BRWD1 BTG3 CCNA2 CCND1 CDC42BPA CFAP298 CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GATD3 GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 HUNK ITGB5 JUN LCOR LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 TTC3 UBE2I UBTF	43 interacting genes: BANP CASP5 CASP7 CLIP2 COPS5 CSNK2A1 CUX1 EP300 EPAS1 FTH1 FUS GABBR1 HIF1A MAD1L1 MAPK14 MGA MNT MSH2 MXD1 MXD3 MXD4 MXI1 MYC MYCL MYCLP1 MYCN PLEKHA5 PLEKHF2 PLIN3 RPL34 RPL35 SMAD3 SMAD4 SNIP1 SPAG9 TAF1 TEAD1 TRRAP TUBA1A TXLNG UNC45A USP1 ZBTB17
Entrez ID		6872	4149
HPRD ID		02436	01113
Ensembl ID		ENSG00000147133	ENSG00000125952
Uniprot IDs		A0A804HIC2 P21675	G3V302 G3V563 G3V5L1 P61244 Q6V3B1 Q8TAX8
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGH 7EGI 7EGJ 7ENA 7ENC 7JJG 7JJH 7JSP 7JTC 7K03 7K0D 7K0U 7K1P 7K27 7K3O 7K42 7K6F 7L6X 7LB0 7LB1 7LB2 7LB3 7N42 7P4S 7T2I 7T36 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS	1AN2 1HLO 1NKP 1NLW 1R05 5EYO 6G6J 6G6K 6G6L 8OTS 8OTT
GO Terms Enriched among Interactors		Transcription Factor TFIID Complex Regulation Of DNA-templated Transcription Initiation RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Positive Regulation Of Transcription Initiation By RNA Polymerase II DNA-templated Transcription Initiation Transcription Initiation At RNA Polymerase II Promoter Nucleoplasm Transcription Preinitiation Complex Assembly DNA-templated Transcription RNA Polymerase II Preinitiation Complex Assembly Protein-DNA Complex Assembly MRNA Transcription Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Factor TFTC Complex DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process Protein-containing Complex Assembly Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Metabolic Process Protein-containing Complex Organization Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Promoter-specific Chromatin Binding Protein Heterodimerization Activity Regulation Of Metabolic Process Nucleic Acid Metabolic Process Cellular Component Assembly	Protein Dimerization Activity Chromatin Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Binding Nucleoplasm DNA Binding Positive Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of MiRNA Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Light Stimulus Regulation Of MiRNA Metabolic Process Response To UV Negative Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Transforming Growth Factor Beta2 Production Response To Radiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Nuclear Receptor Binding Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Neddylation Positive Regulation Of RNA Metabolic Process Intracellular Iron Ion Homeostasis Regulation Of Macromolecule Metabolic Process Striated Muscle Cell Differentiation Macromolecule Biosynthetic Process Negative Regulation Of Catabolic Process