ARHGEF40

Description		Rho guanine nucleotide exchange factor 40
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)
Interacting Genes		7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1
Entrez ID		55701
HPRD ID		13335
Ensembl ID		ENSG00000165801
Uniprot IDs		Q8TER5
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Main Axon Antifungal Humoral Response Regulation Of Superoxide Anion Generation Apolipoprotein Binding Response To Lead Ion Response To Yeast Positive Regulation Of Supramolecular Fiber Organization Astrocyte Activation Neuronal Dense Core Vesicle Memory Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Blood Circulation Positive Regulation Of Cytoskeleton Organization Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Microtubule-based Process Learning Or Memory Cellular Response To Growth Factor Stimulus Cognition Regulation Of Developmental Growth Response To Growth Factor Defense Response To Fungus Response To Fungus Macrophage Activation Antibacterial Humoral Response Amyloid-beta Complex Axon Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Axo-dendritic Transport Cell Body Positive Regulation Of Cellular Component Organization Regulation Of Membrane Potential Positive Regulation Of Protein Localization Defense Response To Gram-negative Bacterium Regulation Of Calcium-mediated Signaling Associative Learning
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