ARHGEF40 and STC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGEF40	STC2
Description		Rho guanine nucleotide exchange factor 40	stanniocalcin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Perinuclear Region Of Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Hormone Activity Enzyme Binding Heme Binding Protein Homodimerization Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Intracellular Calcium Ion Homeostasis Response To Oxidative Stress Embryo Implantation Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Response To Vitamin D Response To Endoplasmic Reticulum Stress Negative Regulation Of Multicellular Organism Growth Response To Peptide Hormone Decidualization Regulation Of Hormone Biosynthetic Process Calcium Ion Homeostasis Cellular Response To Hypoxia Regulation Of Store-operated Calcium Entry
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)	A body shape index ( 34021172) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Height ( 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Immunoglobulin A vasculitis ( 28698626) Prostate cancer ( 23535732) Retinitis pigmentosa ( 33514863) Urate levels in overweight individuals ( 25811787) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1	11 interacting genes: ADAM11 AIFM1 ARHGEF40 ARRB2 CARHSP1 EIF2B3 PEBP1 POLR2C POLR3F PPP1R8 PTN
Entrez ID		55701	8614
HPRD ID		13335	04717
Ensembl ID		ENSG00000165801	ENSG00000113739
Uniprot IDs		Q8TER5	O76061 Q6FHC9
PDB IDs			7Y5Q 8A7D 8A7E 8HGH
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Main Axon Antifungal Humoral Response Regulation Of Superoxide Anion Generation Apolipoprotein Binding Response To Lead Ion Response To Yeast Positive Regulation Of Supramolecular Fiber Organization Astrocyte Activation Neuronal Dense Core Vesicle Memory Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Blood Circulation Positive Regulation Of Cytoskeleton Organization Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Microtubule-based Process Learning Or Memory Cellular Response To Growth Factor Stimulus Cognition Regulation Of Developmental Growth Response To Growth Factor Defense Response To Fungus Response To Fungus Macrophage Activation Antibacterial Humoral Response Amyloid-beta Complex Axon Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Axo-dendritic Transport Cell Body Positive Regulation Of Cellular Component Organization Regulation Of Membrane Potential Positive Regulation Of Protein Localization Defense Response To Gram-negative Bacterium Regulation Of Calcium-mediated Signaling Associative Learning
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