ARHGEF40 and GPSM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF40	GPSM2
Description		Rho guanine nucleotide exchange factor 40	G protein signaling modulator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane	Spindle Pole Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lateral Plasma Membrane Protein-containing Complex Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleotide Binding G-protein Alpha-subunit Binding GDP-dissociation Inhibitor Activity Protein Binding Protein Domain Specific Binding GTPase Regulator Activity Identical Protein Binding Dynein Complex Binding
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Establishment Of Mitotic Spindle Orientation Mitotic Spindle Organization G Protein-coupled Receptor Signaling Pathway Response To Light Intensity Cell Division Maintenance Of Centrosome Location Regulation Of Mitotic Spindle Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Spindle Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle	G alpha (i) signalling events
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)	Fat distribution (HIV) ( 21897333)
Interacting Genes		7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1	17 interacting genes: AGR2 ARHGEF40 DLG4 FXR1 FXR2 GAS2L1 GLIS2 GNAI1 GNAI2 GNAI3 GNAO1 HRAS INSC LRRC8E NRIP1 NUMA1 WHRN
Entrez ID		55701	29899
HPRD ID		13335	06609
Ensembl ID		ENSG00000165801	ENSG00000121957
Uniprot IDs		Q8TER5	B4DIF1 P81274
PDB IDs			3SF4 4WND 4WNE 4WNF 4WNG 5A6C 6HC2
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Main Axon Antifungal Humoral Response Regulation Of Superoxide Anion Generation Apolipoprotein Binding Response To Lead Ion Response To Yeast Positive Regulation Of Supramolecular Fiber Organization Astrocyte Activation Neuronal Dense Core Vesicle Memory Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Blood Circulation Positive Regulation Of Cytoskeleton Organization Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Microtubule-based Process Learning Or Memory Cellular Response To Growth Factor Stimulus Cognition Regulation Of Developmental Growth Response To Growth Factor Defense Response To Fungus Response To Fungus Macrophage Activation Antibacterial Humoral Response Amyloid-beta Complex Axon Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Axo-dendritic Transport Cell Body Positive Regulation Of Cellular Component Organization Regulation Of Membrane Potential Positive Regulation Of Protein Localization Defense Response To Gram-negative Bacterium Regulation Of Calcium-mediated Signaling Associative Learning	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Regulation Of Long-term Neuronal Synaptic Plasticity Heterotrimeric G-protein Complex Regulation Of Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Adenylate Cyclase Regulator Activity Modulation Of Chemical Synaptic Transmission GTPase Activity Ciliary Basal Body Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Periphery GTP Binding Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Long-term Neuronal Synaptic Plasticity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Regulation Of Synaptic Plasticity G Protein Activity G Protein-coupled Receptor Binding GDP Binding Positive Regulation Of Protein Localization To Cell Periphery Cell Division Regulation Of Biological Quality Dendrite Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Translation Regulator Activity Regulation Of Cell Communication Regulation Of Signaling G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Protein Localization Cytoskeletal Anchor Activity Cytoplasm Microtubule Plus-end Dentate Gyrus Development Neuron Projection Negative Regulation Of Secretion By Cell Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Secretion P2Y1 Nucleotide Receptor Binding Negative Regulation Of Transport Cell Cortex Negative Regulation Of Insulin Secretion Positive Regulation Of Metabolic Process Regulation Of Mitotic Spindle Organization Midbody Positive Regulation Of Protein Localization Negative Regulation Of Peptide Secretion
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