ARHGEF40 and TAC1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		ARHGEF40	TAC1
Description		Rho guanine nucleotide exchange factor 40	tachykinin precursor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Extrinsic Component Of Membrane	Extracellular Region Extracellular Space Axon Neuronal Cell Body Synapse Neuronal Dense Core Vesicle
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Substance P Receptor Binding Neuromedin K Receptor Binding Substance K Receptor Binding Receptor Ligand Activity
	Biological Process	Axon Guidance Regulation Of Small GTPase Mediated Signal Transduction	Response To Yeast Positive Regulation Of Acute Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Insemination Long-term Memory Regulation Of Blood Pressure Associative Learning Detection Of Abiotic Stimulus Response To Hormone Negative Regulation Of Heart Rate Positive Regulation Of Epithelial Cell Migration Sensory Perception Of Pain Antibacterial Humoral Response Antifungal Humoral Response Killing Of Cells Of Another Organism Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Lipopolysaccharide Innate Immune Response Positive Regulation Of Action Potential Positive Regulation Of Ossification Response To Pain Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Stress Fiber Assembly Regulation Of Sensory Perception Of Pain Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Sensory Perception Of Pain Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Corticosterone Secretion
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOC GTPase cycle	Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Neuroblastoma (pediatric) ( 32599975) Pediatric nonalcoholic steatohepatitis ( 28918882) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 32888494) Resting heart rate ( 27798624)	Adventurousness ( 30643258) Adverse response to radiation therapy ( 23719583) Blood protein levels ( 30072576) Feeling nervous ( 29500382) General risk tolerance (MTAG) ( 30643258) Regular attendance at a religious group ( 29970889) Response to platinum-based agents ( 22020760) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		7 interacting genes: APP CBY2 GPSM2 MAPT MYCBP STC2 TAC1	10 interacting genes: ARHGEF40 BAG6 CENPB FN1 MEP1A PREP TACR1 TACR2 TACR3 XRCC6
Entrez ID		55701	6863
HPRD ID		13335	08876
Ensembl ID		ENSG00000165801	ENSG00000006128
Uniprot IDs		Q8TER5	P20366 Q9Y494
PDB IDs			2B19 2KS9 2KSA 2KSB 4HOM 7P00 7P02 7RMG 7RMH 7VDM 7XWO 8JBH 8U26
Enriched GO Terms of Interacting Partners?		Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Main Axon Antifungal Humoral Response Regulation Of Superoxide Anion Generation Apolipoprotein Binding Response To Lead Ion Response To Yeast Positive Regulation Of Supramolecular Fiber Organization Astrocyte Activation Neuronal Dense Core Vesicle Memory Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Blood Circulation Positive Regulation Of Cytoskeleton Organization Amyloid Fibril Formation Regulation Of Superoxide Metabolic Process Microglial Cell Activation Leukocyte Activation Involved In Inflammatory Response Regulation Of Microtubule-based Process Learning Or Memory Cellular Response To Growth Factor Stimulus Cognition Regulation Of Developmental Growth Response To Growth Factor Defense Response To Fungus Response To Fungus Macrophage Activation Antibacterial Humoral Response Amyloid-beta Complex Axon Growth Cone Lamellipodium Enzyme Binding Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Histone-dependent DNA Binding Tubulin Complex Microtubule Lateral Binding Axo-dendritic Transport Cell Body Positive Regulation Of Cellular Component Organization Regulation Of Membrane Potential Positive Regulation Of Protein Localization Defense Response To Gram-negative Bacterium Regulation Of Calcium-mediated Signaling Associative Learning	Tachykinin Receptor Activity Positive Regulation Of Uterine Smooth Muscle Contraction Tachykinin Receptor Signaling Pathway Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Positive Regulation Of Smooth Muscle Contraction Regulation Of Cilium Movement Operant Conditioning Positive Regulation Of Muscle Contraction Sperm Midpiece Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Smooth Muscle Contraction Positive Regulation Of Reproductive Process Sperm Head Positive Regulation Of Vascular Permeability Regulation Of Muscle Contraction Positive Regulation Of Blood Pressure Dendrite Membrane Cyclin Binding Regulation Of Reproductive Process Response To Electrical Stimulus Peptide Hormone Processing Regulation Of Hormone Levels Signaling Receptor Ligand Precursor Processing Regulation Of Cell Motility Regulation Of Vascular Permeability Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Regulation Of Biological Quality Smooth Muscle Contraction Regulation Of Microtubule-based Process Substance K Receptor Activity Regulation Of Muscle System Process Substance P Receptor Activity Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Maturation Epidermal Growth Factor Receptor Ligand Maturation Meprin A Complex Oligopeptidase Activity Angiotensin-mediated Drinking Behavior Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Regulation Of Multicellular Organismal Process
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