SAV1

Description		salvador family WW domain containing protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity Molecular Adaptor Activity Transcription Regulator Activator Activity
	Biological Process	Hair Follicle Development Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Keratinocyte Differentiation Hippo Signaling Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Regulation Of Organ Growth Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Keratinocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Stem Cell Population Maintenance
Pathways		Signaling by Hippo
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Dupuytren's disease ( 28886342) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean platelet volume ( 27863252 32888494) Periodontal disease-related phenotype (Socransky) ( 24347629) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: POLE2
Interacting Genes		4 interacting genes: EP300 NEDD4 STK3 STK4
Entrez ID		60485
HPRD ID		06229
Ensembl ID		ENSG00000151748
Uniprot IDs		B3KTQ1 Q9H4B6
PDB IDs		6AO5
Enriched GO Terms of Interacting Partners?		Primitive Hemopoiesis Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Endocardium Development Canonical Wnt Signaling Pathway Neural Tube Formation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Localization To Organelle Hepatocyte Apoptotic Process Hemopoiesis Positive Regulation Of Hippo Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Embryonic Epithelial Tube Formation Hippo Signaling Protein Stabilization Wnt Signaling Pathway Epithelial Tube Formation Negative Regulation Of Organ Growth Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction System Development Apoptotic Signaling Pathway Establishment Of Protein Localization To Organelle Regulation Of Hippo Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Epithelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Organ Growth Positive Regulation Of Intracellular Signal Transduction Developmental Growth Regulation Of Protein Stability Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Fat Cell Differentiation Protein Serine/threonine Kinase Activator Activity Cellular Response To UV Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Protein Transport Formation Of Structure Involved In A Symbiotic Process Protein Tetramerization Positive Regulation Of Hepatocyte Apoptotic Process
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