SAV1 and STK4

Number of citations of the paper that reports this interaction (PMID 16930133)
27

Data Source:
HPRD (in vivo, in vitro)

		SAV1	STK4
Gene Name		salvador family WW domain containing protein 1	serine/threonine kinase 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Hair Follicle Development Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Maintenance	Cell Morphogenesis Patterning Of Blood Vessels Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EP300 RASSF1 STK3 STK4	16 interactors: AKT1 CASP3 CNKSR1 CSN1S1 HIST2H2BE IL2RG LATS1 MBP NEDD4 PRKRIR RASSF1 RASSF5 SAV1 SGMS1 SIRT1 TP53
Entrez ID		60485	6789
HPRD ID		06229	05395
Ensembl ID		ENSG00000151748	ENSG00000101109
Uniprot IDs		Q9H4B6	Q13043
PDB IDs			2JO8 3COM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Binding Protein Stabilization Positive Regulation Of Binding Primitive Hemopoiesis Regulation Of Protein Stability Regulation Of Protein Binding Endocardium Development Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Binding Hippo Signaling Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Heart Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Growth Tube Development Regulation Of Organ Growth Chordate Embryonic Development Embryonic Placenta Development Positive Regulation Of Cellular Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Histone H2B Acetylation Regulation Of Fat Cell Differentiation Neural Tube Formation Cardiovascular System Development Positive Regulation Of Protein Modification Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Tube Formation Programmed Cell Death Morphogenesis Of Embryonic Epithelium Anatomical Structure Formation Involved In Morphogenesis Cell Death Death Intrinsic Apoptotic Signaling Pathway Epithelium Development Placenta Development Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Cellular Protein Metabolic Process	Response To Cytokine Positive Regulation Of Protein Metabolic Process Hippo Signaling Intracellular Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Helicase Activity Response To Stimulus Response To UV Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Aging Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Response To Radiation Response To Organic Substance Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Protein Kinase Activity Apoptotic Mitochondrial Changes Cellular Response To Stimulus Response To Stress Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Programmed Cell Death Keratinocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Neuron Death Cell Death Cellular Response To Hypoxia Death Positive Regulation Of Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Autophagy Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Aging Cellular Response To Oxygen Levels Negative Regulation Of Cell Proliferation Response To Light Stimulus Apoptotic Signaling Pathway
Tagcloud ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	abl1 centered coactivator damage elicits hematologic hematological inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Intersection) ?		hippo