SAV1 and STK3

Number of citations of the paper that reports this interaction (PMID 15688006)
75

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SAV1	STK3
Gene Name		salvador family WW domain containing protein 1	serine/threonine kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Hair Follicle Development Keratinocyte Differentiation Hippo Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Lung Epithelial Cell Differentiation Intestinal Epithelial Cell Differentiation Regulation Of Stem Cell Maintenance	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Phosphorylation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Signaling by Hippo	Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: EP300 RASSF1 STK3 STK4	33 interactors: AKT1 CASP3 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX QARS RAF1 RASSF1 RASSF2 RASSF4 RASSF5 SAV1 SLMAP SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		60485	6788
HPRD ID		06229	05433
Ensembl ID		ENSG00000151748	ENSG00000104375
Uniprot IDs		Q9H4B6	B3KYA7 Q13188
PDB IDs			4HKD 4L0N 4LG4 4LGD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Binding Protein Stabilization Positive Regulation Of Binding Primitive Hemopoiesis Regulation Of Protein Stability Regulation Of Protein Binding Endocardium Development Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Binding Hippo Signaling Embryonic Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Negative Regulation Of Organ Growth Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Fat Cell Differentiation Intracellular Signal Transduction Heart Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Growth Tube Development Regulation Of Organ Growth Chordate Embryonic Development Embryonic Placenta Development Positive Regulation Of Cellular Metabolic Process Embryo Development Ending In Birth Or Egg Hatching Histone H2B Acetylation Regulation Of Fat Cell Differentiation Neural Tube Formation Cardiovascular System Development Positive Regulation Of Protein Modification Process Embryonic Epithelial Tube Formation Epithelial Tube Formation Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Process Tube Formation Programmed Cell Death Morphogenesis Of Embryonic Epithelium Anatomical Structure Formation Involved In Morphogenesis Cell Death Death Intrinsic Apoptotic Signaling Pathway Epithelium Development Placenta Development Negative Regulation Of Wnt Signaling Pathway Neural Tube Development Positive Regulation Of Cellular Protein Metabolic Process	Hippo Signaling Intracellular Signal Transduction Response To Stimulus Signaling Cell Communication Keratinocyte Differentiation Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Stimulus Regulation Of Cellular Protein Metabolic Process Epidermal Cell Differentiation Cell Death Death Negative Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Protein Kinase Activity Nitric Oxide Biosynthetic Process Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Skin Development Negative Regulation Of Kinase Activity Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Kinase Activity Mitotic Cell Cycle Phase Transition Regulation Of Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Epidermis Development Cellular Response To Organic Substance Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Reactive Oxygen Species Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Epithelial Cell Differentiation Negative Regulation Of Oxidative Stress-induced Cell Death
Tagcloud ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics sav1 scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Difference) ?		adaptor contributing driving extensively flies gna11 gnaq gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents taz team uveal ww45 yap	contextdependent crossroads fat1 fat2 fat3 fat4 fathippo frmd1 frmd6 gammasecretase lamellipodia membraneassociated mob1a mob1b mpdz mpp5 mupp1 pals1 preball prognostics scribblebinding stemcell stk4 vapsbinding wwc1 wwc2 wwtr1 yap1
Tagcloud (Intersection) ?		sav1