SST and SSTR2

Number of citations of the paper that reports this interaction (PMID 1346068)
51

Data Source:
HPRD (in vivo)

		SST	SSTR2
Gene Name		somatostatin	somatostatin receptor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Hormone Activity	Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding
	Biological Process	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone	Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Cerebellum Development Peristalsis Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs		Cysteamine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	9 interactors: APP CORT GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST
Entrez ID		6750	6752
HPRD ID		08920	01674
Ensembl ID		ENSG00000157005
Uniprot IDs		P61278	P30874
PDB IDs		1P2W
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Vocalization Behavior Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adult Behavior G-protein Coupled Receptor Signaling Pathway Synapse Organization Growth Hormone Receptor Signaling Pathway Synaptic Transmission Cellular Response To Growth Hormone Stimulus Signaling Cell Communication Social Behavior Response To Growth Hormone Learning Or Memory Cognition Response To Organonitrogen Compound Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Hormone Apoptotic Process Programmed Cell Death T Cell Costimulation Neuromuscular Process Controlling Balance Synapse Assembly Determination Of Affect NFAT Protein Import Into Nucleus Cell Death Death Associative Learning Response To Stress Single-organism Behavior Response To Peptide Hormone Signal Transduction Response To Peptide Abortive Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Transcription Factor Import Into Nucleus Regulation Of Receptor Activity Memory Neuromuscular Process Cellular Response To Hormone Stimulus
Tagcloud ?		additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast	analogue appropriate braf cancers detecting dish entero extensive gastro give gives highlighted humanized immunohistochemistry kras list mutational nets neuroendocrine next ngs octreotide others particular pathologists perform rapidy somatostatin suitable
Tagcloud (Difference) ?		additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast	analogue appropriate braf cancers detecting dish entero extensive gastro give gives highlighted humanized immunohistochemistry kras list mutational nets neuroendocrine next ngs octreotide others particular pathologists perform rapidy somatostatin suitable
Tagcloud (Intersection) ?