SST and SSTR4

Number of citations: 0 (PubMedID 8100352)
Data Source: HPRD (in vivo)

		SST	SSTR4
Name		somatostatin	somatostatin receptor 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Neuronal Cell Body GABA-ergic Synapse Neuronal Dense Core Vesicle	Plasma Membrane Membrane Neuron Projection
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding Neuropeptide Binding
	Biological Process	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Response To Acidic PH Regulation Of Cell Migration Somatostatin Signaling Pathway Response To Amino Acid Response To Steroid Hormone Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Negative Regulation Of Cell Population Proliferation Somatostatin Signaling Pathway Cellular Response To Glucocorticoid Stimulus
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		None	Somatostatin Lutetium Lu 177 dotatate
GWAS		Pursuit maintenance gain ( 29064472 ) Skin pigmentation ( 28300201 )	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Blood sugar levels ( 29403010 ) Hypothyroidism ( 27182965 ) Mitochondrial DNA copy number ( 30704525 ) Obesity-related traits ( 23251661 ) Vitamin D levels ( 26704534 )
Novel Interactors		1 novel interactors: FXR1	None recorded
Interacting Genes		6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	2 interacting genes: CORT SST
Entrez ID		6750	6754
HPRD ID		08920	01676
Ensembl ID		ENSG00000157005	ENSG00000132671
Uniprot IDs		P61278	P31391
PDB IDs		2MI1 7T10 7WIC 7WJ5 7XAT 7XMR 7XMS 7Y27	7XMS 7XMT
GO Terms Enriched among Interactors		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Neuron Projection Hormone-mediated Signaling Pathway G Protein-coupled Receptor Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Glucocorticoid Cellular Response To Lipid Response To Corticosteroid Response To Steroid Hormone Cellular Response To Estradiol Stimulus Response To Lipid Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Response To Hormone Hormone-mediated Apoptotic Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Protein Retention In ER Lumen Positive Regulation Of Long-term Neuronal Synaptic Plasticity Disulfide Oxidoreductase Activity Nuclear Pore Complex Assembly Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Folding In Endoplasmic Reticulum Nuclear Pore Organization Costamere Ribonucleoprotein Granule Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Protein Disulfide Isomerase Activity	Receptor Ligand Activity Hormone Activity Trans-synaptic Signaling Synaptic Signaling Chemical Synaptic Transmission Somatostatin Signaling Pathway Hormone-mediated Apoptotic Signaling Pathway Signaling Cell-cell Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway Neuropeptide Hormone Activity Regulation Of Cell Motility Regulation Of Cell Migration Digestion Neuronal Dense Core Vesicle Response To Acidic PH Hyperosmotic Response Regulation Of Locomotion Response To PH Extracellular Space G Protein-coupled Receptor Binding Response To Osmotic Stress Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway GABA-ergic Synapse Response To Amino Acid Extracellular Region Response To Nutrient Hormone-mediated Signaling Pathway Response To Steroid Hormone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway