SST and SSTR3

Number of citations of the paper that reports this interaction (PubMedID 1337145)
0

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SST	SSTR3
Description		somatostatin	somatostatin receptor 3
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Neuronal Cell Body GABA-ergic Synapse Neuronal Dense Core Vesicle	Plasma Membrane Cilium Membrane Neuron Projection Ciliary Membrane Non-motile Cilium
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding Receptor Ligand Activity	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Signaling Receptor Binding Protein Binding Neuropeptide Binding
	Biological Process	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Chemical Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Xenobiotic Stimulus Response To Acidic PH Regulation Of Cell Migration Somatostatin Signaling Pathway Response To Amino Acid Response To Steroid Hormone Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Hormone-mediated Apoptotic Signaling Pathway Somatostatin Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates transcription of neuronal ligands	Peptide ligand-binding receptors G alpha (i) signalling events BBSome-mediated cargo-targeting to cilium
Drugs			Pasireotide Somatostatin Lutetium Lu 177 dotatate Edotreotide gallium Ga-68
Diseases
GWAS		Pursuit maintenance gain ( 29064472) Skin pigmentation ( 28300201)
Interacting Genes		6 interacting genes: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	5 interacting genes: CORT GNAI1 LNX1 SST TP53
Entrez ID		6750	6753
HPRD ID		08920	01675
Ensembl ID		ENSG00000157005	ENSG00000278195
Uniprot IDs		P61278	P32745
PDB IDs		2MI1 7T10 7WIC 7WJ5 7XAT 7XMR 7XMS 7Y27	8XIQ 8XIR
Enriched GO Terms of Interacting Partners?		Somatostatin Receptor Activity Somatostatin Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Neuron Projection Hormone-mediated Signaling Pathway G Protein-coupled Receptor Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Negative Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway Cellular Response To Steroid Hormone Stimulus Response To Glucocorticoid Cellular Response To Lipid Response To Corticosteroid Response To Steroid Hormone Cellular Response To Estradiol Stimulus Response To Lipid Regulation Of Cell Population Proliferation Cellular Response To Hormone Stimulus Response To Estradiol Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Response To Hormone Hormone-mediated Apoptotic Signaling Pathway RNA Strand Annealing Activity Nuclear Pore Localization Intracellular Membraneless Organelle Protein Retention In ER Lumen Positive Regulation Of Long-term Neuronal Synaptic Plasticity Disulfide Oxidoreductase Activity Nuclear Pore Complex Assembly Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Maintenance Of Protein Localization In Endoplasmic Reticulum Protein Folding In Endoplasmic Reticulum Nuclear Pore Organization Costamere Ribonucleoprotein Granule Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Skeletal Muscle Organ Development Protein Disulfide Isomerase Activity	Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Telomere Maintenance Via Telomerase Response To Xenobiotic Stimulus Disordered Domain Specific Binding Regulation Of Neuroblast Proliferation Gastrulation T Cell Differentiation In Thymus Negative Regulation Of Gliogenesis Regulation Of Telomere Maintenance Via Telomere Lengthening Neuroblast Proliferation Apoptotic Signaling Pathway Synaptic Signaling Signaling Cell Communication Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Receptor Ligand Activity Hormone Activity Cell-cell Signaling G Protein-coupled Receptor Binding Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Gliogenesis Stem Cell Differentiation Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Centrosome Beta-catenin-ICAT Complex Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Neuron Apoptotic Process Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Negative Regulation Of Nervous System Development Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of Fibroblast Proliferation Lung Induction Regulation Of Telomere Maintenance Neural Precursor Cell Proliferation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development
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