SST and SSTR3

Number of citations of the paper that reports this interaction (PMID 1337145)
16

Data Source:
BioGRID (unspecified method)
HPRD (in vivo)

		SST	SSTR3
Gene Name		somatostatin	somatostatin receptor 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Neuronal Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Nonmotile Primary Cilium Neuron Projection Ciliary Membrane
	Molecular Function	Hormone Activity	Somatostatin Receptor Activity Protein Binding Neuropeptide Binding
	Biological Process	Hyperosmotic Response Cell Surface Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Synaptic Transmission Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Response To Heat Regulation Of Cell Migration Response To Drug Response To Amino Acid Response To Steroid Hormone	Organelle Organization G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Negative Regulation Of Cell Proliferation Hormone-mediated Apoptotic Signaling Pathway Cerebellum Development Forebrain Development Somatostatin Signaling Pathway Response To Starvation Regulation Of Insulin Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes BBSome-mediated cargo-targeting to cilium GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Cysteamine
Diseases
GWAS
Protein-Protein Interactions		6 interactors: PDIA2 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5	5 interactors: CORT GNAI1 LNX1 SST TP53
Entrez ID		6750	6753
HPRD ID		08920	01675
Ensembl ID		ENSG00000157005	ENSG00000183473
Uniprot IDs		P61278	P32745 Q86YF2
PDB IDs		1P2W
Enriched GO Terms of Interacting Partners?		Somatostatin Signaling Pathway Cellular Response To Estradiol Stimulus Neuropeptide Signaling Pathway Cellular Response To Estrogen Stimulus Hormone-mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Steroid Hormone Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Organic Cyclic Compound Response To Estradiol Cellular Response To Lipid Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Steroid Hormone Response To Peptide Response To Glucocorticoid Response To Corticosteroid Cellular Response To Hormone Stimulus Synaptic Transmission Response To Estrogen Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Response To Lipid Response To Organic Cyclic Compound Cell-cell Signaling Response To Hormone G-protein Coupled Receptor Signaling Pathway Forebrain Development Cerebellum Development Metencephalon Development Regulation Of Cell Proliferation Hindbrain Development Response To Starvation Brain Development Cellular Response To Organic Substance Head Development Central Nervous System Development Response To Organic Substance Response To Nutrient Levels Response To Extracellular Stimulus Spermatogenesis Male Gamete Generation Cell Surface Receptor Signaling Pathway Digestion Gamete Generation Cellular Response To Stimulus Sexual Reproduction	Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Response To Osmotic Stress Synaptic Transmission Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cell-cell Signaling Negative Regulation Of Helicase Activity G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Aging Positive Regulation Of Thymocyte Apoptotic Process Hormone-mediated Apoptotic Signaling Pathway Mitochondrial DNA Repair Cell Surface Receptor Signaling Pathway Regulation Of Mitochondrion Degradation T Cell Proliferation Involved In Immune Response B Cell Lineage Commitment Glial Cell Apoptotic Process Oxidative Stress-induced Premature Senescence Apoptotic Signaling Pathway ER Overload Response Negative Regulation Of Macroautophagy Stress-induced Premature Senescence Positive Regulation Of T Cell Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Strand Renaturation DNA Damage Response, Signal Transduction Resulting In Transcription Mitotic Cell Cycle Arrest Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Blood Coagulation Hemostasis Protein Oligomerization Response To Nutrient Levels Regulation Of Thymocyte Apoptotic Process Replicative Senescence Positive Regulation Of Mitochondrial Membrane Permeability Determination Of Adult Lifespan Positive Regulation Of Lymphocyte Apoptotic Process Circadian Behavior Response To Extracellular Stimulus Mitochondrial DNA Metabolic Process Positive Regulation Of Histone Deacetylation Rhythmic Behavior Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Protein Oligomerization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process RRNA Transcription Response To Drug
Tagcloud ?		additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast	3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr1 sstr2 sstr4 sstr5 sstrs stimulating sw480 tcf wnt
Tagcloud (Difference) ?		additional allow alphac barley cdna cerevisiae encoding entry fructan fructosyltransferase fusion hordeum incubated methylotrophic pastoris pichia ppicz produced pronounced saccharomyces secreted secretory sft sucrose transformed translational vector vulgare yeast	3beta analog catenin colon colonic downregulated elucidated gsk immunocytochemistry inactivated ladder methodology modulation myc numerous octreotide preliminary promoted somatostatin sstr1 sstr2 sstr4 sstr5 sstrs stimulating sw480 tcf wnt
Tagcloud (Intersection) ?