RPS6KB2 and RPS6

Number of citations of the paper that reports this interaction (PMID 16810323)
33

Data Source:
HPRD (in vitro)

		RPS6KB2	RPS6
Gene Name		ribosomal protein S6 kinase, 70kDa, polypeptide 2	ribosomal protein S6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding Peptide Binding	Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Translation Protein Phosphorylation Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Kinase B Signaling Innate Immune Response Positive Regulation Of Translational Initiation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	Ribosomal Small Subunit Assembly G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Gastrulation Insulin Receptor Signaling Pathway Gene Expression Viral Process Viral Life Cycle Viral Transcription Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Erythrocyte Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling Peptide chain elongation IGF1R signaling cascade Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex IRS-related events triggered by IGF1R Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Insulin receptor signalling cascade Translation SRP-dependent cotranslational protein targeting to membrane S6K1 signalling Eukaryotic Translation Termination IRS-related events Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits PKB-mediated events Eukaryotic Translation Elongation PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ATP5A1 BRAF BTK COASY CSNK2B EEF2K EP300 FBXO25 IKBKG KAT2B LYN MAPK8IP2 MTOR NEDD4L PDPK1 PRKCE RPS6 SRC SRPK1 SYK	12 interactors: ATF4 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH RPS4X RPS6KB1 RPS6KB2 STAU1 UPF2
Entrez ID		6199	6194
HPRD ID		10203	01592
Ensembl ID		ENSG00000175634	ENSG00000137154
Uniprot IDs		Q9UBS0	A2A3R5 A2A3R6 P62753
PDB IDs			3J3A
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Phosphorylation Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Phosphate-containing Compound Metabolic Process Intracellular Signal Transduction Regulation Of Kinase Activity Viral Process Regulation Of Phosphorus Metabolic Process Innate Immune Response Protein Autophosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Organic Substance Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Response To Hormone Immune Response Protein Phosphorylation Response To Peptide Hormone Defense Response Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Response To Insulin Response To Peptide Cellular Protein Metabolic Process Cellular Response To Organic Substance Signal Transduction Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Signaling Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Cellular Response To Insulin Stimulus Cell Communication Positive Regulation Of Protein Modification Process Immune System Process Fc-epsilon Receptor Signaling Pathway Peptidyl-amino Acid Modification Peptidyl-tyrosine Autophosphorylation Cell Activation Cellular Metabolic Process	Positive Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Protein Kinase B Signaling Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Translation Response To Glucagon Regulation Of Protein Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Innate Immune Response Response To Stress Response To Clozapine Regulation Of Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Positive Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Cellular Protein Metabolic Process Glucose Metabolic Process Positive Regulation Of Transferase Activity Skeletal Muscle Atrophy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Nuclear-transcribed MRNA Catabolic Process RNA Localization Liver Development Carbohydrate Biosynthetic Process Cellular Response To Growth Factor Stimulus Immune System Process MRNA Catabolic Process Striated Muscle Atrophy Response To Leucine Immune Response Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Phosphorylation Defense Response Muscle Atrophy
Tagcloud ?		administrated arylnaphthalide atg12 atg5 autophagic bafilomycin beclin bnip3 chloroquine inc ja justicia justicidin lc3 lignan methyladenine mrfp p62 p70s6k pdk1 periodicals physiol procumbens ptflc3 puncta shrna sqstm1 vad wiley	acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Difference) ?		administrated arylnaphthalide atg12 atg5 autophagic bafilomycin beclin bnip3 inc ja justicia justicidin lc3 lignan methyladenine mrfp p62 p70s6k pdk1 periodicals physiol procumbens ptflc3 puncta shrna sqstm1 vad wiley	acidified autophagy basally chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Intersection) ?		chloroquine