SRM and TNFRSF14

Data Source: HiPPIP (Novel)

		SRM	TNFRSF14
Name		spermidine synthase	TNF receptor superfamily member 14
Structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Catalytic Activity Spermidine Synthase Activity Protein Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Virus Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Ubiquitin Protein Ligase Binding Receptor Ligand Activity
	Biological Process	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermidine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Adaptive Immune Response Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of T Cell Proliferation Innate Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Symbiont Entry Into Host Cell Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of T Cell Migration
Pathways		Metabolism of polyamines	TNFs bind their physiological receptors Co-inhibition by BTLA Co-inhibition by BTLA
GWAS		Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Beard thickness ( 26926045 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Autoimmune thyroid disease ( 32581359 ) Body mass index ( 26426971 ) Celiac disease ( 20190752 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Inflammatory bowel disease ( 28067908 ) Medication use (thyroid preparations) ( 31015401 ) Multiple sclerosis ( 28445677 ) Primary sclerosing cholangitis ( 23603763 ) Rheumatoid arthritis ( 24390342 24449572 18794853 30423114 ) Ulcerative colitis ( 26398853 28067908 23128233 21297633 )
Novel Interactors		2 novel interactors: ASXL1 TNFRSF14	9 novel interactors: ANGPTL7 ENO1 MASP2 NDST2 NID2 POLR1A RPL22 SRM UNC93A
Interacting Genes		4 interacting genes: CDC42 CEBPA SOX12 TERF1	30 interacting genes: A2M APP BTLA CD160 CEP126 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		6723	8764
HPRD ID		01692	04122
Ensembl ID		ENSG00000116649	ENSG00000157873
Uniprot IDs		P19623	B9A034 Q92956
PDB IDs		2O05 2O06 2O07 2O0L 3RW9	1JMA 2AW2 4FHQ 4RSU 5T2Q 5T2R 6NG3 7MSG
GO Terms Enriched among Interactors		Positive Regulation Of Cell Adhesion Macrophage Differentiation GBD Domain Binding Storage Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 Positive Regulation Of Cell Activation C/EBP Complex Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Adaptive Immune Memory Response Endothelin Receptor Signaling Pathway Involved In Heart Process Myeloid Leukocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Regulation Of Cell Activation Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway White Fat Cell Proliferation PR-DUB Complex Positive Regulation Of Metabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Adhesion Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Phenylpropanoid Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Establishment Of Golgi Localization Spindle DNA Binding Fat Cell Proliferation Meiotic Telomere Clustering	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Identical Protein Binding CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Signaling Receptor Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Biosynthetic Process Signaling Adaptor Activity Regulation Of Immune Response Regulation Of Apoptotic Process Regulation Of DNA-binding Transcription Factor Activity Regulation Of Programmed Cell Death Positive Regulation Of Macromolecule Biosynthetic Process Tumor Necrosis Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Histone Deacetylase Complex Apoptotic Process Nitric-oxide Synthase Regulator Activity Programmed Cell Death Cell Death Transcription Corepressor Binding Positive Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Glial Cell Apoptotic Process CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Apoptotic Signaling Pathway Enzyme Binding Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Protein Deacetylation Protein Lysine Deacetylase Activity Regulation Of Nitric Oxide Metabolic Process Regulation Of Immune System Process Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Type II Interferon Production Immune System Process Regulation Of ATP Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity