SRM and SOX12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SRM	SOX12
Description		spermidine synthase	SRY-box transcription factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Chromatin Nucleus Nucleoplasm Protein-DNA Complex
	Molecular Function	Catalytic Activity Spermidine Synthase Activity Protein Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Polyamine Metabolic Process Polyamine Biosynthetic Process Spermidine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Brain Development Spinal Cord Development Neuron Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Camera-type Eye Morphogenesis
Pathways		Metabolism of polyamines
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Beard thickness ( 26926045)	Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		4 interacting genes: CDC42 CEBPA SOX12 TERF1	3 interacting genes: POLD2 SMAD4 SRM
Entrez ID		6723	6666
HPRD ID		01692	09056
Ensembl ID		ENSG00000116649	ENSG00000177732
Uniprot IDs		P19623	O15370
PDB IDs		2O05 2O06 2O07 2O0L 3RW9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Adhesion Macrophage Differentiation GBD Domain Binding Storage Vacuole RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 Positive Regulation Of Cell Activation C/EBP Complex Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Adaptive Immune Memory Response Endothelin Receptor Signaling Pathway Involved In Heart Process Myeloid Leukocyte Differentiation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Fat Cell Differentiation CHOP-C/EBP Complex Regulation Of Cell Activation Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway White Fat Cell Proliferation PR-DUB Complex Positive Regulation Of Metabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Adhesion Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Response To Phenylpropanoid Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Telomerase Activity Shelterin Complex Ankyrin Repeat Binding Lung Saccule Development Bone Marrow Development Regulation Of Kidney Size Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Establishment Of Golgi Localization Spindle DNA Binding Fat Cell Proliferation Meiotic Telomere Clustering	Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Spermidine Synthase Activity Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Spermidine Biosynthetic Process SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation Delta DNA Polymerase Complex Zeta DNA Polymerase Complex Spermidine Metabolic Process Atrioventricular Canal Development Somite Rostral/caudal Axis Specification Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Cardiac Muscle Cell Differentiation Endothelial Cell Activation Error-prone Translesion Synthesis Cardiac Muscle Hypertrophy In Response To Stress Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Negative Regulation Of Cardiocyte Differentiation Secondary Palate Development Filamin Binding Neural Crest Cell Differentiation Heart Valve Formation DNA Strand Elongation Involved In DNA Replication Polyamine Biosynthetic Process Positive Regulation Of Cardiac Muscle Cell Apoptotic Process I-SMAD Binding Cardiac Conduction System Development Interleukin-6-mediated Signaling Pathway Gastrulation With Mouth Forming Second Regulation Of Cell Proliferation Involved In Heart Morphogenesis Polyamine Metabolic Process Regulation Of Cardiac Muscle Cell Differentiation
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