RAB11B and RAB11FIP5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vitro)

		RAB11B	RAB11FIP5
Description		RAB11B, member RAS oncogene family	RAB11 family interacting protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endosome Early Endosome Golgi Apparatus Plasma Membrane Cilium Membrane Nuclear Speck Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Mitochondrial Membrane Centriolar Satellite Ciliary Basal Body Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding	Protein Binding Small GTPase Binding Gamma-tubulin Binding
	Biological Process	Receptor Recycling Protein Transport Melanosome Transport Endocytic Recycling Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Monoatomic Anion Transport Constitutive Secretory Pathway Regulated Exocytosis Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance By Transcytosis Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling	Protein Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulated Exocytosis Negative Regulation Of Adiponectin Secretion Cellular Response To Acidic PH Regulation Of Protein Localization To Cell Surface
Pathways		TBC/RABGAPs RAB geranylgeranylation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Non-word reading ( 30741946) Pediatric areal bone mineral density (spine vs radius & hip discordant skeletal phenotype) ( 29240982) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		11 interacting genes: APP IKBKG MEOX2 MYO5B OPTN PRKG2 RAB11FIP2 RAB11FIP3 RAB11FIP5 SNCA SREBF2	10 interacting genes: ARF6 NAPG RAB11A RAB11B RAB11FIP4 RAB14 RAB25 RO60 TRIM21 YWHAG
Entrez ID		9230	26056
HPRD ID		05009	16117
Ensembl ID		ENSG00000185236	ENSG00000135631
Uniprot IDs		Q15907	A0A1B0GTL5 Q9BXF6
PDB IDs		2F9L 2F9M 4OJK
Enriched GO Terms of Interacting Partners?		Recycling Endosome Regulation Of Protein Localization Recycling Endosome Membrane Negative Regulation Of Adiponectin Secretion Vesicle-mediated Transport Cytoplasmic Vesicle Membrane Positive Regulation Of Protein Localization Negative Regulation Of Transport Establishment Of Localization In Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Small GTPase Binding Regulated Exocytosis Identical Protein Binding Regulation Of Amyloid-beta Clearance Regulation Of Neurotransmitter Uptake Endosome Regulation Of Autophagy Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Negative Regulation Of Secretion By Cell Regulation Of Receptor Recycling K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Small Molecule Metabolic Process Amyloid Fibril Formation Signal Release Endocytosis Microglial Cell Activation Positive Regulation Of Defense Response Negative Regulation Of Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Exocytosis Regulation Of Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Localization Positive Regulation Of Catabolic Process Protein Localization To Cell Periphery Insulin Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Myosin V Binding G Protein Activity Endocytic Recycling Recycling Endosome Membrane Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Endosomal Transport Protein Localization To Cleavage Furrow GTPase Activity GTP Binding Vesicle-mediated Transport Positive Regulation Of Epithelial Cell Migration Cleavage Furrow Positive Regulation Of Mitotic Cytokinetic Process Establishment Of Protein Localization Golgi Apparatus Amyloid-beta Clearance By Transcytosis Cytoplasmic Vesicle Extracellular Exosome Regulation Of Epithelial Cell Migration GDP Binding Localization Within Membrane Phagocytic Vesicle Regulation Of Cytokinesis Positive Regulation Of Mitotic Cytokinesis Protein Transport Regulation Of Mitotic Cytokinesis Intracellular Protein Localization Positive Regulation Of Cell Cycle Intracellular Transport Transcytosis Regulation Of Endocytic Recycling Endosome Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Melanosome Localization Pigment Granule Localization Protein K6-linked Ubiquitination Amyloid-beta Clearance Protein Localization To Cell Surface Regulation Of Cell Division Regulation Of Protein Localization Cellular Localization Establishment Of Localization In Cell Regulation Of Protein Localization To Cell Surface Exocytosis Vesicle Docking Involved In Exocytosis Hydrolase Activity Intracellular Protein Transport
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