RAB11B

Description		RAB11B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Cytosol Synaptic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Synapse Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Myosin V Binding Cadherin Binding
	Biological Process	Receptor Recycling Protein Transport Melanosome Transport Endocytic Recycling Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Monoatomic Anion Transport Constitutive Secretory Pathway Regulated Exocytosis Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance By Transcytosis Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling
Pathways		TBC/RABGAPs RAB geranylgeranylation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)
Novel Interacting Genes		1 novel interacting genes: TYK2
Interacting Genes		11 interacting genes: APP IKBKG MEOX2 MYO5B OPTN PRKG2 RAB11FIP2 RAB11FIP3 RAB11FIP5 SNCA SREBF2
Entrez ID		9230
HPRD ID		05009
Ensembl ID		ENSG00000185236
Uniprot IDs		Q15907
PDB IDs		2F9L 2F9M 4OJK
Enriched GO Terms of Interacting Partners?		Recycling Endosome Regulation Of Protein Localization Recycling Endosome Membrane Negative Regulation Of Adiponectin Secretion Vesicle-mediated Transport Cytoplasmic Vesicle Membrane Positive Regulation Of Protein Localization Negative Regulation Of Transport Establishment Of Localization In Cell Insulin Secretion Involved In Cellular Response To Glucose Stimulus Small GTPase Binding Regulated Exocytosis Identical Protein Binding Regulation Of Amyloid-beta Clearance Regulation Of Neurotransmitter Uptake Endosome Regulation Of Autophagy Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Presynapse Assembly Cellular Response To Copper Ion Negative Regulation Of Secretion By Cell Regulation Of Receptor Recycling K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Small Molecule Metabolic Process Amyloid Fibril Formation Signal Release Endocytosis Microglial Cell Activation Positive Regulation Of Defense Response Negative Regulation Of Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Copper Ion Negative Regulation Of Signaling Negative Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Protein Localization To Plasma Membrane Golgi To Plasma Membrane Protein Transport Regulation Of Macroautophagy Polyubiquitin Modification-dependent Protein Binding Exocytosis Regulation Of Transport Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Localization Positive Regulation Of Catabolic Process Protein Localization To Cell Periphery Insulin Secretion Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion
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