KPNB1 and CSE1L

Number of citations of the paper that reports this interaction (PMID 9323134)
153

Data Source:
HPRD (in vitro)

		KPNB1	CSE1L
Gene Name		karyopherin (importin) beta 1	CSE1 chromosome segregation 1-like (yeast)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	Protein Binding Importin-alpha Export Receptor Activity Ran GTPase Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Protein Export From Nucleus Apoptotic Process Cell Proliferation
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	15 interactors: CDH1 HNRNPL KPNA1 KPNA2 KPNA4 KPNA6 KPNB1 MAPK6 PPP5C RAN RPL22 STAT1 TMEM62 YWHAG YWHAQ
Entrez ID		3837	1434
HPRD ID		04114	03217
Ensembl ID			ENSG00000124207
Uniprot IDs		B7Z752 B7ZAV6 Q14974	P55060
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Protein Targeting NLS-bearing Protein Import Into Nucleus Protein Import Into Nucleus Nuclear Import Protein Import Protein Localization To Nucleus Intracellular Protein Transport Cellular Protein Localization Establishment Of Protein Localization To Organelle Establishment Of Protein Localization Nucleocytoplasmic Transport Nuclear Transport Protein Localization To Organelle Protein Localization Protein Transport Intracellular Transport Cytoplasmic Transport Cellular Localization Establishment Of Localization In Cell Viral Process Intracellular Transport Of Virus Viral Life Cycle Cytokine-mediated Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Intracellular Transport Apoptotic Process Execution Phase Of Apoptosis Programmed Cell Death Cellular Response To Cytokine Stimulus Cell Death Death DNA Metabolic Process Response To Organic Substance Response To Cytokine Cellular Response To Organic Substance Apoptotic DNA Fragmentation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Transport Signal Transduction Cellular Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Nuclear Changes Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Cell Communication Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Establishment Of Protein Localization Transport
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	accord activators aspartyl biomolecular cathepsin cd138 curve cyclooxygenase distinctly done egr1 erbb2 h1 immunohistochemical lin28 met minus nasopharyngeal nm23 p63 prognostic segregation separated stainings stat5 stratify syndecan transducers usual
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	accord activators aspartyl biomolecular cathepsin cd138 curve cyclooxygenase distinctly done egr1 erbb2 h1 lin28 met minus nasopharyngeal nm23 p63 prognostic segregation separated stainings stat5 stratify syndecan transducers usual
Tagcloud (Intersection) ?		immunohistochemical