KPNB1 and TAF3

Number of citations of the paper that reports this interaction (PubMedID 15870280)
49

Data Source:
BioGRID (pull down)

		KPNB1	TAF3
Description		karyopherin subunit beta 1	TATA-box binding protein associated factor 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Membrane Nuclear Membrane Protein-containing Complex Specific Granule Lumen NLS-dependent Protein Nuclear Import Complex Extracellular Exosome Endoplasmic Reticulum Tubular Network Ficolin-1-rich Granule Lumen	Male Germ Cell Nucleus Nucleus Nucleoplasm Transcription Factor TFIID Complex Nuclear Membrane
	Molecular Function	RNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Enzyme Binding Protein Domain Specific Binding Small GTPase Binding Hsp90 Protein Binding Nuclear Import Signal Receptor Activity Importin-alpha Family Protein Binding	P53 Binding Protein Binding Zinc Ion Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding Protein Heterodimerization Activity Histone H3K4me3 Reader Activity Transcription Regulator Inhibitor Activity
	Biological Process	RNA Import Into Nucleus Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Chromosome Alignment Protein Transport Astral Microtubule Organization Positive Regulation Of Hippo Signaling Establishment Of Mitotic Spindle Localization Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Maintenance Of Protein Location In Nucleus Positive Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Regulation of cholesterol biosynthesis by SREBP (SREBF) Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Nuclear import of Rev protein Nuclear import of Rev protein Initiation of Nuclear Envelope (NE) Reformation Neutrophil degranulation Assembly of the ORC complex at the origin of replication Interferon alpha/beta signaling Postmitotic nuclear pore complex (NPC) reformation Inhibition of nitric oxide production SARS-CoV-1 activates/modulates innate immune responses Maturation of hRSV A proteins	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Asthma ( 31619474) Body mass index ( 26426971) Glycine levels ( 30837465) HDL cholesterol ( 30275531) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference adjusted for BMI ( 34021172) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 22190364) Optic cup area ( 25631615) Simvastatin-induced myopathy ( 31220337) Total cholesterol levels ( 33339817) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Asthma ( 31959851) Cadmium levels ( 26025379) Red blood cell count ( 32888494)
Interacting Genes		75 interacting genes: AMFR CCNB1 CCNE1 CD99 CDC25C CEBPA CHD3 CRBN CSE1L CSNK1A1 CUL4B DSCAM ELAVL1 EPAS1 EXO1 FGFR1 H1-0 H1-2 IGFBP3 IGFBP5 IPO7 IPO8 ITCH KPNA1 KPNA2 KPNA3 KPNA6 LBR LINC01554 LYST MESD MSL1 MTNR1A NFATC1 NFYA NOSIP NUP153 NUP50 NUP54 NUP62 NUP98 OGT PIAS4 PLCD1 PRKD3 PTEN PTHLH PTMA PTN PTPN2 RAN RANBP2 RANBP3 RBX1 RNF10 RPL5 RUNX1T1 SELENOS SENP2 SMAD2 SMAD3 SMN1 SMNDC1 SNAI1 SNAPIN SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5	6 interacting genes: H3-4 H3C1 HMGB1 KPNA2 KPNB1 TAF10
Entrez ID		3837	83860
HPRD ID		04114	19377
Ensembl ID		ENSG00000108424	ENSG00000165632
Uniprot IDs		B7Z752 Q14974	A0A8I5KR98 Q5VWG9
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW 3W5K 6N88 6N89 8GCN	5C13 5WXG 5WXH 5XMY 6MZD 6MZL 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7EGD 7EGE 7EGF 7EGI 7EGJ 7ENA 7ENC 8GXQ 8GXS 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Protein Import Into Nucleus Import Into Nucleus Nucleoplasm Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Transport Protein Localization To Organelle Positive Regulation Of Nucleobase-containing Compound Metabolic Process NLS-dependent Protein Nuclear Import Complex Viral Penetration Into Host Nucleus Nuclear Localization Sequence Binding Establishment Of Protein Localization Intracellular Protein Localization NLS-bearing Protein Import Into Nucleus Positive Regulation Of RNA Metabolic Process Nuclear Envelope Intracellular Transport Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Cellular Localization Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Transport Nuclear Import Signal Receptor Activity Intracellular Transport Of Virus Regulation Of Macromolecule Metabolic Process Host Cell Cytoplasm Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Differentiation Nuclear Membrane Protein Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Transport Establishment Of Localization In Cell Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Ubiquitin-ubiquitin Ligase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process	NLS-dependent Protein Nuclear Import Complex Positive Regulation Of Viral Life Cycle NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Protein-DNA Complex Assembly Chromatin Remodeling Chromatin Organization Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Viral Process SAGA Complex Assembly Transferase Activity, Transferring One-carbon Groups Thymidylate Synthase Activity Regulation Of Transcription Initiation By RNA Polymerase II Adenylate Cyclase Regulator Activity Regulation Of DNA Metabolic Process Regulation Of Mismatch Repair Regulation Of DNA-templated Transcription Initiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex T-helper 1 Cell Activation Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Regulation Of Viral Life Cycle Ficolin-1-rich Granule Lumen Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Negative Regulation Of Apoptotic Cell Clearance Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Regulation Of Viral Process Mitotic Chromosome Movement Towards Spindle Pole Import Into Nucleus Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Viral Penetration Into Host Nucleus Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Lateral Mesodermal Cell Differentiation Allantois Development DTMP Biosynthetic Process Pyrimidine Deoxyribonucleoside Monophosphate Biosynthetic Process DTTP Biosynthetic Process Nucleosome Nucleosome Assembly Nucleosome Organization Spermatogonial Cell Division
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