SQLE and CREB3L1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SQLE	CREB3L1
Name		squalene epoxidase	cAMP responsive element binding protein 3 like 1
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Squalene Monooxygenase Activity Protein Binding Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Lipid Droplet Formation Response To Biphenyl	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Unfolded Protein Negative Regulation Of Gene Expression Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	CREB3 factors activate genes
Drugs		Naftifine Terbinafine Butenafine Ellagic acid	None
GWAS		Amyotrophic lateral sclerosis ( 24931836 ) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836 ) Metabolite levels ( 23823483 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Fasting blood glucose ( 22581228 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol ( 30275531 ) Medication use (diuretics) ( 31015401 ) Offspring birth weight ( 31043758 ) Peripheral artery disease ( 31285632 ) Schizophrenia ( 29483656 ) Serum metabolite levels ( 33031748 ) Systolic blood pressure ( 30578418 )
Interacting Genes		8 interacting genes: ALDOC BCL2L13 CREB3 CREB3L1 MARCHF6 REEP4 TMEM14B ZNF641	195 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARLN ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CFTR CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35H1 SLC39A2 SLC39A9 SLC52A1 SLC61A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1
Entrez ID		6713	90993
HPRD ID		11802	16751
Ensembl ID		ENSG00000104549	ENSG00000157613
Uniprot IDs		Q14534	B2RA75 Q96BA8
PDB IDs		6C6N 6C6P 6C6R	Not available
GO Terms Enriched among Interactors		ADP Catabolic Process Pyruvate Metabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Response To Endoplasmic Reticulum Stress ER Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Response To Unfolded Protein Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Fructose-bisphosphate Aldolase Activity Extracellular Matrix Constituent Secretion Glucose Metabolic Process Nucleoside Phosphate Catabolic Process Release From Viral Latency ATP Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Metabolic Process Carbohydrate Derivative Metabolic Process CAMP Response Element Binding Protein Binding Mitotic Nuclear Membrane Reassembly Negative Regulation Of Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process CAMP Response Element Binding Fructose Metabolic Process Endoplasmic Reticulum Mannose Trimming	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity Lipid Metabolic Process Lipid Biosynthetic Process Golgi Membrane Sterol Biosynthetic Process Steroid Biosynthetic Process SNARE Complex Sterol Metabolic Process Membrane Lipid Metabolic Process Cholesterol Biosynthetic Process Structural Constituent Of Myelin Sheath Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Plasma Membrane Endomembrane System Leukotriene-C4 Synthase Activity Transmembrane Transport Chloride Channel Inhibitor Activity Organic Anion Transport Mitochondrial Membrane Small Molecule Biosynthetic Process Cholesterol Metabolic Process Sphingolipid Metabolic Process Establishment Of Protein Localization Membrane Fusion Steroid Metabolic Process Heme Biosynthetic Process Myelination Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Axon Ensheathment Vesicle Fusion CAMP Response Element Binding Protein Binding Bleb Assembly Membrane Organization Nuclear Envelope Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Organelle Membrane Fusion Azurophil Granule CDP-diacylglycerol Biosynthetic Process Carbohydrate Derivative Transport Syntaxin Binding Cellular Localization CDP-diacylglycerol Metabolic Process Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Leukotriene Metabolic Process