SQLE

Description		squalene epoxidase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Squalene Monooxygenase Activity Protein Binding Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding
	Biological Process	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Lipid Droplet Formation Response To Biphenyl
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)
Drugs		Naftifine Terbinafine Butenafine Ellagic acid
Diseases
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: ALDOC BCL2L13 CREB3 CREB3L1 MARCHF6 REEP4 TMEM14B ZNF641
Entrez ID		6713
HPRD ID		11802
Ensembl ID		ENSG00000104549
Uniprot IDs		Q14534
PDB IDs		6C6N 6C6P 6C6R
Enriched GO Terms of Interacting Partners?		ADP Catabolic Process Pyruvate Metabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Response To Endoplasmic Reticulum Stress ER Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Response To Unfolded Protein Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Fructose-bisphosphate Aldolase Activity Extracellular Matrix Constituent Secretion Glucose Metabolic Process Nucleoside Phosphate Catabolic Process Release From Viral Latency ATP Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Metabolic Process Carbohydrate Derivative Metabolic Process CAMP Response Element Binding Protein Binding Mitotic Nuclear Membrane Reassembly Negative Regulation Of Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process CAMP Response Element Binding Fructose Metabolic Process Endoplasmic Reticulum Mannose Trimming
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