SQLE and MARCHF6

Number of citations: 57 (PubMedID 36958722)
Data Source: BioGRID (protein complementation assay)

		SQLE	MARCHF6
Name		squalene epoxidase	membrane associated ring-CH-type finger 6
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle	ER Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Squalene Monooxygenase Activity Protein Binding Oxidoreductase Activity Flavin Adenine Dinucleotide Binding FAD Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Ubiquitin-specific Protease Binding
	Biological Process	Lipid Metabolic Process Cholesterol Biosynthetic Process Cholesterol Metabolic Process Sterol Metabolic Process Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Lipid Droplet Formation Response To Biphenyl	Cholesterol Biosynthetic Process Proteasomal Protein Catabolic Process Protein Ubiquitination ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Protein K48-linked Ubiquitination Endoplasmic Reticulum Mannose Trimming
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	ER Quality Control Compartment (ERQC)
Drugs		Naftifine Terbinafine Butenafine Ellagic acid	None
GWAS		Amyotrophic lateral sclerosis ( 24931836 ) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836 ) Metabolite levels ( 23823483 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: ALDOC BCL2L13 CREB3 CREB3L1 MARCHF6 REEP4 TMEM14B ZNF641	12 interacting genes: ADGRE2 BUD31 DIO2 MSMO1 MTNR1B RGS2 SQLE UBC UBE2D2 UBE2G1 UBE2G2 UBE2J2
Entrez ID		6713	10299
HPRD ID		11802	11095
Ensembl ID		ENSG00000104549	ENSG00000145495
Uniprot IDs		Q14534	O60337
PDB IDs		6C6N 6C6P 6C6R	Not available
GO Terms Enriched among Interactors		ADP Catabolic Process Pyruvate Metabolic Process ADP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Glycolytic Process Ribonucleoside Diphosphate Catabolic Process Response To Endoplasmic Reticulum Stress ER Ubiquitin Ligase Complex Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Deacetylase Activity Negative Regulation Of Response To Endoplasmic Reticulum Stress Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Diphosphate Metabolic Process Response To Unfolded Protein Endoplasmic Reticulum Membrane Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Catabolic Process Nicotinamide Nucleotide Metabolic Process Carbohydrate Catabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Fructose-bisphosphate Aldolase Activity Extracellular Matrix Constituent Secretion Glucose Metabolic Process Nucleoside Phosphate Catabolic Process Release From Viral Latency ATP Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Organophosphate Catabolic Process Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Fructose 1,6-bisphosphate Metabolic Process Negative Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Cholesterol Metabolic Process Carbohydrate Derivative Metabolic Process CAMP Response Element Binding Protein Binding Mitotic Nuclear Membrane Reassembly Negative Regulation Of Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process CAMP Response Element Binding Fructose Metabolic Process Endoplasmic Reticulum Mannose Trimming	Ubiquitin Conjugating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Cholesterol Biosynthetic Process Post-translational Protein Modification ATP Binding Sterol Biosynthetic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Squalene Monooxygenase Activity Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Membrane Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity Nucleotide Binding Negative Regulation Of Glycine Import Across Plasma Membrane Proteolysis Thyroxine 5'-deiodinase Activity Thyroxine 5-deiodinase Activity Thyroid Hormone Catabolic Process Steroid Biosynthetic Process C-4 Methylsterol Oxidase Activity Response To Biphenyl Catabolic Process ERAD Pathway Melatonin Receptor Activity Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Adenylate Cyclase Inhibitor Activity